Inventors:
Carl Nathan - Larchmont NY, US
Gang Lin - Forest Hills NY, US
Assignee:
CORNELL RESEARCH FOUNDATION, INC. - Ithaca NY
International Classification:
A61K 31/41, A61K 31/422, A61K 31/427, A61K 31/4245, A61K 31/433, A61K 31/4439, A61K 31/501, A61K 31/506, A61K 31/497, C07D 419/04, A61P 35/00, A61P 31/06, A61P 31/00, A61P 31/04, A61P 31/08
US Classification:
51425205, 514360, 514378, 514374, 514365, 514372, 514364, 514361, 514362, 514342, 514256, 51425505, 548122, 514380, 514376, 514377, 514369, 514370
Abstract:
The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.