Inventors:
Philip J. Scarpace - Gainesville FL, US
Gang Li - Gainesville FL, US
Assignee:
University of Florida Research Foundation, Incorporated - Gainesville FL
International Classification:
A61K 48/00, A61K 31/711, A61P 3/00
Abstract:
Disclosed are methods for the use of pro-opiomelanocortin-encoding polynucleotides in the creation of transformed host cells and transgenic animals. In particular, the use of recombinant adeno-associated viral (rAAV) vector compositions, virions, and pluralities of virus particles that comprise a nucleic acid segment that expresses one or more mammalian pro-opiomelanocortin polypeptides in suitably transformed host cells is described. Also disclosed are methods for the treatment and amelioration of symptoms of a variety of conditions and disorders in an animal, including hyperinsulinemia, obesity, adiposity, overeating, and related eating disorders.