Inventors:
Fritz Henn - East Patchogue NY, US
Assignee:
Brookhaven Science Associates, LLC - Upton NY
International Classification:
A61K 31/54, C07D 285/22, C07D 211/72, A61K 31/44, A61K 31/13, C07C 211/00
US Classification:
5142232, 544 12, 546306, 514353, 514663, 564463
Abstract:
Methods for treatment of depression-related mood disorders in mammals, particularly humans are disclosed. The methods of the invention include administration of compounds capable of enhancing glutamate transporter activity in the brain of mammals suffering from depression. ATP-sensitive Kchannel openers and β-lactam antibiotics are used to enhance glutamate transport and to treat depression-related mood disorders and depressive symptoms.