Inventors:
Frank S. Caruso - Colts Neck NJ
Fredrick L. Minn - Blue Bell PA
John W. Lyle - Belmar NJ
Assignee:
Algos Pharmaceutical Corporation - Neptune NJ
International Classification:
A61K 922, A61K 952
Abstract:
The analgesic effectiveness of tramadol is significantly enhanced by administering tramadol prior to, with or following the administration of an analgesia enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.