FREDERICK S BUCKNER
Osteopathic Medicine at Pacific St, Seattle, WA

2008031, Dec 18, 2008

Mar 17, 2006

11/886105

Andrew Hamilton - Guilford CT, US
Frederick Buckner - Seattle WA, US
Matthew Glenn - Queensland, AU
Wesley Van Voorhis - Seattle WA, US
Said Sebti - Tampa FL, US

University of Washington - Seattle WA

A61K 31/4439, C07D 403/02, A61K 31/4178, A61P 35/00, A61P 33/06, C07D 401/02

514341, 5483127, 5462751, 514397

Formula (I): Where Ris an optionally substituted C-Chydrocarbyl group (preferably a cyclic alkyl group), an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group; R is a C(O)R′ group (preferably forming an optionally substituted C-Cacyl group), or a S(O)R′ group, where y is 0 or 1 and x is 0, 1 or 2 and R′ is H or an optionally substituted C-Calkyl group, or R′ is an optionally substituted C-Ccycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group; R, R, R, R, Rand Rare each independently selected from H, an optionally substituted C-Chydrocarbyl group, including a C-Ccycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group or an optionally substituted heteroaromatic group, or Rand R, Rand Ror Rand Rtogether form a keto (C═O) group; Ris H, an optionally substituted C-Chydrocarbyl group, an optionally substituted heterocyclic group, an optionally substituted aromatic group, or an optionally substituted heteroaromatic group; A is Formula (II): a Formula (III): group, or a Formula (IV) or Formula (V) group, where Z is N, O or S; Ris H, a C-Coptionally substituted hydrocarbyl group or an optionally substituted aromatic group; n is from 0 to 3; and pharmaceutically acceptable salts thereof. Compounds according to the invention are useful in one or more aspects to inhibit farnesyl transferase, or to treat malaria, neoplasia, a hyperproliferative disease state or arthritis, including rheumaroid arthritis or osteoarthritis.