DR. FREDERICK NAFTOLIN, MD
Medical Practice at Stonewall Ln, New Haven, CT
License number
Connecticut 021019
Category
Medical Practice
Type
Obstetrics & Gynecology
License number
Connecticut 20310
Category
Medical Practice
Type
Obstetrics & Gynecology
Address
Address
4 Stonewall Ln, New Haven, CT 06525
Phone
(203) 298-9315
(203) 387-6068 (Fax)
(203) 387-6068 (Fax)
Professional information
Dr. Frederick Naftolin, Woodbridge CT - MD (Doctor of Medicine)
Specialties:
Obstetrics & Gynecology
Address:
4 Stonewall Ln, Woodbridge 06525
(203) 298-9315 (Phone)
(203) 298-9315 (Phone)
Certifications:
Obstetrics & Gynecology, 1972
Awards:
Healthgrades Honor Roll
Languages:
English
Education:
Medical School
University of California At San Francisco
Graduated: 1961
King Co Hosp
University Of California-Los Angeles
Oxford U
University Of Washington
University of California At San Francisco
Graduated: 1961
King Co Hosp
University Of California-Los Angeles
Oxford U
University Of Washington
Methods For Direct Biomolecule Identification By Matrix-Assisted Laser Desorption Ionization (Maldi) Mass Spectrometry
US Patent:
2007011, May 24, 2007
Filed:
Sep 29, 2006
Appl. No.:
11/541380
Inventors:
Paul Pevsner - New York NY, US
Frederick Naftolin - Woodbridge CT, US
Douglas Miller - Belle Mead NJ, US
Dean Hillman - New Hyde Park NY, US
Brian Stall - Bedford NH, US
Steven Wishnies - Columbia MD, US
Frederick Naftolin - Woodbridge CT, US
Douglas Miller - Belle Mead NJ, US
Dean Hillman - New Hyde Park NY, US
Brian Stall - Bedford NH, US
Steven Wishnies - Columbia MD, US
International Classification:
B01D 59/44
US Classification:
250282000
Abstract:
The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
Methods For Direct Biomolecule Identification By Matrix-Assisted Laser Desorption Ionization (Maldi) Mass Spectrometry
US Patent:
8525104, Sep 3, 2013
Filed:
Apr 27, 2010
Appl. No.:
12/799576
Inventors:
Paul Pevsner - New York NY, US
Frederick Naftolin - Woodbridge CT, US
Douglas C. Miller - Belle Mead NJ, US
Dean Hillman - New Hyde Park NY, US
Brian K. Stall - Bedford NH, US
Steven M. Wishnies - Columbia MD, US
Frederick Naftolin - Woodbridge CT, US
Douglas C. Miller - Belle Mead NJ, US
Dean Hillman - New Hyde Park NY, US
Brian K. Stall - Bedford NH, US
Steven M. Wishnies - Columbia MD, US
Assignee:
New York University - New York NY
International Classification:
B01D 59/44, H01J 49/00, H01J 49/40
US Classification:
250281, 250288, 250282
Abstract:
The present invention relates to the use of post source decay (PSD) or collision induced dissociation (CID) direct tissue (DT) MALDI-TOF or DT-MALDI-TOF-TOF mass spectrographic identification of biological molecules in a tissue or cellular sample without the need for further protein extraction. This method provides for studying cells or tissues by direct tissue MALDI (DT-MALDI), thereby substituting in situ protein release for further protein extraction. Mass/intensity data was processed with Mascot© software interrogation of the NCBI database. These results are proof of principle that DT-MALDI, combined with bioinformatics, can directly identify proteins in cells and tissues from their mass spectra.
Methods For Preparation Of Live Body Tissues For Examination
US Patent:
2007011, May 17, 2007
Filed:
Sep 28, 2006
Appl. No.:
11/541403
Inventors:
Paul Pevsner - New York NY, US
Frederick Naftolin - Woodbridge CT, US
Ahmed Metwaly - New Haven CT, US
Erol Gulcicek - Madison CT, US
Frederick Naftolin - Woodbridge CT, US
Ahmed Metwaly - New Haven CT, US
Erol Gulcicek - Madison CT, US
International Classification:
A61K 51/00, A01N 1/02, A61K 49/04, C12Q 1/00
US Classification:
424001110, 424009400, 435001100, 435004000
Abstract:
A minimally invasive procedure for perfusion-impregnation of tissues, organs and cells is provided that aids in the retention of tissue and cellular architecture without the formation of artifacts. The procedure allows for monitoring drug disposition, for detecting diseased tissue and for monitoring the presence of target molecules in a sample using various imaging techniques, including matrix assisted laser desorption ionization mass spectrometry (MALDI-MS).
Erm Family Binding Agents And Their Use In Diagnosis And Treatment Of Proliferative Conditions
US Patent:
2009029, Dec 3, 2009
Filed:
Jul 27, 2005
Appl. No.:
11/658214
Inventors:
Frederick Naftolin - Woodbridge CT, US
Assignee:
Yale University - New Haven CT
International Classification:
A61K 39/395, C12Q 1/02
US Classification:
4241381, 435 71
Abstract:
The methods and compositions of the invention provide new diagnostic markers for cancers (e.g., ovarian cancer, PPC, etc.) and other proliferative diseases or conditions such as psoriasis and endometriosis. The methods and compositions of the invention further provide new treatments for such proliferative diseases or conditions.