Inventors:
Douglas F. Nixon - San Francisco CA, US
Keith Garrison - Alameda CA, US
Duncan Meiklejohn - West Lebanon NH, US
Mario Ostrowski - Toronto, CA
R. Bradley Jones - Toronto, CA
Ashish Agrawal - Fremont CA, US
Frederick M. Hecht - San Francisco CA, US
Assignee:
THE J. DAVID GLADSTONE INSTITUTES - San Francisco CA
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 38/08, C07K 7/06, C07H 21/04, C07K 7/08, A61P 31/18, C12N 15/63, A61K 31/7088, A61K 38/10, C12Q 1/02, A61P 35/00, A61P 31/12
US Classification:
514 37, 514 216, 530328, 536 231, 530327, 4353201, 514 44 R, 514 38, 514 215, 435 29
Abstract:
The present invention provides LINE polypeptides; and compositions, including immunogenic compositions, comprising a subject LINE polypeptide. The present invention provides a recombinant nucleic acid comprising a nucleotide sequence encoding a subject LINE polypeptide. A subject composition is useful for stimulating a T-cell immune response to a LINE peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers that are associated with tissues in which LINE polypeptides are aberrantly expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a LINE polypeptide.