Inventors:
Thomas P. Bridge - Washington DC
Frederick K. Goodwin - Chevy Chase MD
Assignee:
The United States of America as represented by the Secretary of Health
and Human Services - DC
International Classification:
A61K 3702
Abstract:
The present invention relates to a method of treating chronic fatigue syndrome not associated with an HIV infection. In the method of the present invention patients are administered a pharmaceutically acceptable carrier together with
(1) a neuropsychiatrically effective amount of a linear peptide of formula (I):
R. sup. a -Ser-Thr-Thr-Thr-Asn-Tyr-R. sup. 6 (I)
wherein
R. sup. a is Ala, D-Ala or Cys-Ala-, and
R. sup. 6 is Thr, Thr-amide, Thr-Cys or Thr-Cys-amide,
or a derivative of the peptide or a physiologically acceptable salt thereof; or
(2) a neuropsychiatrically effective amount of a linear peptide of formula (II):
R. sup. 1 -R. sup. 2 -R. sup. 3 -R. sup. 4 -R. sup. 5 (II)
wherein
R. sup. 1 is X-Y or Y when Y is Thr-, Ser-, Asn-, Leu-, Ile-, Arg- or Glu-, and X is Cys;
R. sup.