FREDERICK H WILSON
Osteopathic Medicine at York St, New Haven, CT
License number
Connecticut 56941
Category
Osteopathic Medicine
Type
Hematology
License number
Connecticut 56941
Category
Osteopathic Medicine
Type
Medical Oncology
Address
Address
20 York St #NP4, New Haven, CT 06510
Phone
(203) 200-5864
(203) 688-3501 (Fax)
(203) 688-3501 (Fax)
Professional information
Compositions Methods And Kits Relating To Treating And Diagnosing Hypertension
US Patent:
2003008, May 1, 2003
Filed:
Jul 17, 2002
Appl. No.:
10/196935
Inventors:
Richard Lifton - Guilford CT, US
Frederick Wilson - New Haven CT, US
Keith Choate - New Haven CT, US
Carol Nelson-Williams - Hamden CT, US
Kazuhiko Ishikawa - Toyonaka City, JP
Frederick Wilson - New Haven CT, US
Keith Choate - New Haven CT, US
Carol Nelson-Williams - Hamden CT, US
Kazuhiko Ishikawa - Toyonaka City, JP
International Classification:
C12N009/12, C07H021/04, C12P021/02, C12N005/06
US Classification:
435/069100, 435/194000, 435/320100, 435/325000, 536/023200
Abstract:
The present invention relates to novel nucleic acids encoding a mammalian WNK, and proteins encoded thereby, preferably, human WNK1 and human WNK4. These novel nucleic acids, and mutant forms thereof, are associated with, inter alia, renal electrolyte handling, hypertension, and pseudohypoaldosterism type II (PHA II). That is, the present invention relates to novel mutations (e.g., deletions and missense mutations in an exon, intron, or both, of a nucleic acid encoding a WNK) that mediate and/or are associated with altered expression, among other things. These mutations are, in turn, associated with and/or mediate disease (e.g., hypertension, PHA II, and the like). Thus, these nucleic acids provide a novel target for treatment, diagnosis, and development of therapeutics to treat these diseases.