Inventors:
Juan Fueyo - Houston TX, US
Athanassios Kyritsis - Stavraki, GR
Polly Lee - Houston TX, US
Victor Levin - Houston TX, US
Charles Conrad - Spring TX, US
Frederick Lang - Houston TX, US
International Classification:
A61K048/00, C12N007/00, C12N015/861
US Classification:
424/093200, 435/235100, 435/456000
Abstract:
The present invention involves a method of treating cancer using a mutant adenovirus that is targeted to cells with a mutant retinoblastoma pathway. The mutant adenovirus is able to kill the tumor cells without harming the cells with a wild type retinoblastoma pathway.