Inventors:
David Y. Jackson - Belmont CA, US
Frederick C. Sailes - Norcross GA, US
Daniel P. Sutherlin - San Carlos CA, US
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 31/5375, C07C 271/40, A61K 31/27, C07D 263/58, A61K 31/421, C07D 217/00, A61K 31/47, C07D 215/00, C07D 265/30, C07D 241/04, A61K 31/495, C07C 229/00, A61K 31/195, A61P 19/02, A61P 11/06, A61P 17/00, A61P 1/00
US Classification:
5142375, 560115, 514490, 548221, 514375, 546147, 514307, 546153, 514312, 544169, 544389, 51425501, 562449, 514563
Abstract:
The compounds of the invention are inhibitors of alpha4 containing integrin-mediated binding to ligands such as VCAM-1 and MAdCAM.