FREDERICK C MILLER
Medical Practice at 42 St, Tampa, FL

2003019, Oct 16, 2003

Feb 18, 2003

10/369427

Frederick Miller - Tampa FL, US
Lance Ausec - St. Pete Beach FL, US

A61K009/48

424/451000

A multi-compartment capsule including a primary capsule and a secondary capsule selectively positionable within an internal periphery of the primary capsule. The secondary capsule includes a base, a corresponding cap and one or more receiving chambers. Each of the receiving chambers of the secondary capsule may be formed having an internal periphery sufficient for receiving at least one active ingredient or medicament (e.g., nutraceutical, vitamin, dietary supplement, mineral or combination thereof) therein. Similarly, the primary capsule may be formed having a base, a corresponding cap and one or more receiving chambers. The receiving chambers of the primary capsule are preferably formed having an internal periphery sufficient for receiving the secondary capsule, together with one or more active ingredients or medicaments (e.g., nutraceutical, vitamin, dietary supplement, mineral or combination thereof) therein. The active ingredient(s) in the primary capsule having a physical state (i.e., solid, liquid, gas or dispersion) different from the physical state of the active ingredient(s) in the secondary capsule. In addition, the component parts of the multi-compartment capsule may include various time-release coatings to facilitate the release and ultimately the absorption of the active ingredients introduced in the different receiving chambers to release at different release rates. Moreover, the cap of the primary capsule may be configured in such a manner or a filling material may be introduced into the internal periphery of the cap which generally eliminates or substantially reduces any potential dead space volume within the primary capsule, thereby functionally negating the opportunity for reaction between an air bubble and one or more of the active ingredients introduced into the primary capsule in an effort to improve stability of the capsular ingredient(s).

2003019, Oct 16, 2003

Feb 18, 2003

10/369247

Frederick Miller - Tampa FL, US
Lance Ausec - St. Pete Beach FL, US

A61K009/48, B31B001/60, B29C039/10

424/451000, 156/060000, 264/004000

An encapsulation process for forming a multi-compartment capsule. The process comprising the steps of: (1) providing a primary capsule having a base and a cap; (2) providing a secondary capsule having a base and a cap; (3) introducing at least one ingredient having a first physical state (i.e., solid, liquid, gas or dispersion) into a receiving chamber within the internal periphery of the secondary capsule; (4) positioning the cap of the secondary capsule into a sealing relationship with the base of the secondary capsule; (5) introducing at least one ingredient having a second physical state (i.e., solid, liquid, gas or dispersion) into a receiving chamber within the internal periphery of the primary capsule; (6) introducing the secondary capsule into the internal periphery of the primary capsule; and positioning the cap of the primary capsule into a sealing relationship with the base of the primary capsule. The ingredients introduced within the primary and secondary capsules comprise at least one active ingredient or medicament (e.g., pharmaceutical, biotechnical, nutraceutical, vitamin, dietary supplement, mineral or combination thereof). The component parts of the multi-compartment capsule may include various time-release coatings to facilitate release of active ingredient(s) or medicaments at different rates. The capsular cap may be configured in such a manner or a filling material may be introduced into the cap to substantially reduce any potential dead space volume within the capsule, thereby minimizing the opportunity for reaction between an air bubble and one or more of the active ingredients introduced into the capsule.

2003019, Oct 16, 2003

Feb 18, 2003

10/369244

Frederick Miller - Tampa FL, US
Lance Ausec - St. Pete Beach FL, US

A61K009/48

424/451000

A multi-compartment capsule including a primary capsule and a secondary capsule selectively positionable within an internal periphery of the primary capsule. The secondary capsule includes a base, a corresponding cap and one or more receiving chambers. Each of the receiving chambers of the secondary capsule may be formed having an internal periphery sufficient for receiving at least one active ingredient or medicament (e.g., pharmaceutical, biotechnical, nutraceutical, vitamin, dietary supplement, mineral or combination thereof) therein. Similarly, the primary capsule may be formed having a base, a corresponding cap and one or more receiving chambers. The receiving chambers of the primary capsule are preferably formed having an internal periphery sufficient for receiving the secondary capsule, together with one or more active ingredients or medicaments (e.g., pharmaceutical, biotechnical, nutraceutical, vitamin, dietary supplement, mineral or combination thereof) therein. The active ingredient(s) in the primary capsule having a physical state (i.e., solid, liquid, gas or dispersion) different from the physical state of the active ingredient(s) in the secondary capsule. In addition, the component parts of the multi-compartment capsule may include various time-release coatings to facilitate the release and ultimately the absorption of the active ingredients introduced in the different receiving chambers to release at different release rates. Moreover, the cap of the primary capsule may be configured in such a manner or a filling material may be introduced into the internal periphery of the cap which generally eliminates or substantially reduces any potential dead space volume within the primary capsule, thereby functionally negating the opportunity for reaction between an air bubble and one or more of the active ingredients introduced into the primary capsule in an effort to improve stability of the capsular ingredient(s).

2003019, Oct 16, 2003

Feb 18, 2003

10/368951

Frederick Miller - Tampa FL, US
Lance Ausec - St. Pete Beach FL, US

A61K009/48, B29C039/10

424/451000, 264/004000, 156/060000

An encapsulation process for forming a multi-compartment capsule. The process comprising the steps of: (1) providing a primary capsule having a base and a cap; (2) providing a secondary capsule having a base and a cap; (3) introducing at least one ingredient having a first physical state (i.e., solid, liquid, gas or dispersion) into a receiving chamber within the internal periphery of the secondary capsule; (4) positioning the cap of the secondary capsule into a sealing relationship with the base of the secondary capsule; (5) introducing at least one ingredient having a second physical state (i.e., solid, liquid, gas or dispersion) into a receiving chamber within the internal periphery of the primary capsule; (6) introducing the secondary capsule into the internal periphery of the primary capsule; and positioning the cap of the primary capsule into a sealing relationship with the base of the primary capsule. The ingredients introduced within the primary and secondary capsules comprise at least one active ingredient or medicament (e.g., pharmaceutical, biotechnical, nutraceutical, vitamin, dietary supplement, mineral or combination thereof). The component parts of the multi-compartment capsule may include various time-release coatings to facilitate release of active ingredient(s) or medicaments at different rates. The capsular cap may be configured in such a manner or a filling material may be introduced into the cap to substantially reduce any potential dead space volume within the capsule, thereby minimizing the opportunity for reaction between an air bubble and one or more of the active ingredients introduced into the capsule.