Inventors:
Richard A. Flavell - Killingworth CT
Fred S. Kantor - Orange CT
Stephen W. Barthold - Madison CT
Erol Fikrig - Guilford CT
Assignee:
Yale University - New Haven CT
International Classification:
A61K 3902
US Classification:
536 237, 536 234, 4352523, 4353201, 435 691, 435 693, 435 711, 435 712, 4242031, 4242001, 4241901, 4241921, 4241841, 4241851
Abstract:
Methods and compositions for the prevention and diagnosis of Lyme disease. OspA and OspB polypeptides and serotypic variants thereof, which elicit in a treated animal the formation of an immune response which is effective to treat or protect against Lyme disease as caused by infection with. Anti-OspA and anti-OspB antibodies that are effective to treat or protect against Lyme disease as caused by infection with. A screening method for the selection of those OspA and OspB polypeptides and anti-OspA and anti-OspB antibodies that are useful for the prevention and detection of Lyme disease. Diagnostic kits including OspA and OspB polypeptides or antibodies directed against such polypeptides.