Inventors:
Xiaoqun Jiang - Quincy MA
E. Antonio Chiocca - Wakefield MA
Elliott Kieff - Brookline MA
Fred Wang - Chestnut Hill MA
Fred Hochberg - Chestnut Hill MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12N 1500
US Classification:
4353201, 435325, 435455, 514 44
Abstract:
The present invention relates to a viral vector system derived from Epstein-Barr Virus (EBV), where the transgene is effectively inserted into the EBV major internal repeat region (IR1) without adverse affect on EBV latent or lytic function. The vector of the invention can target and stably transform B-lymphocyte cells, both in culture and in vivo.