FRED DOUGLAS FINKELMAN, MD
Osteopathic Medicine at Piedmont Ave, Cincinnati, OH

License number

Ohio 35.068656

Professional information

Professor At University Of Cincinnati College Of Medicine

Position:

Professor at University of Cincinnati College of Medicine, Professor at Cincinnati Childrens Hospital Medical Center, McDonald Professor of Medicine at University of Cincinnati Sch of Medicine, McDonald Professor of Medicine at University of Cincinnati School of Medicine, McDonald Professor of Medicine, Professor of Pediatrics at University of Cincinnati

Location:

Cincinnati Area

Industry:

Research

Work:

University of Cincinnati College of Medicine - Professor Cincinnati Childrens Hospital Medical Center since 2005 - Professor University of Cincinnati Sch of Medicine since 1995 - McDonald Professor of Medicine University of Cincinnati School of Medicine since 1995 - McDonald Professor of Medicine University of Cincinnati since 1995 - McDonald Professor of Medicine, Professor of Pediatrics

Education:

Yale University School of Medicine 1967 - 1971

Dr. Fred D Finkelman, Cincinnati OH - MD (Doctor of Medicine)

Specialties:

Rheumatology

Address:

222 Piedmont Ave STE 6000, Cincinnati 45219
(513) 475-8522 (Phone), (513) 475-7327 (Fax)
University of Cincinnati RHU
231 Albert Sabin Way, Cincinnati 45267
(513) 558-4701 (Phone)

Conditions:

Arthritis, Calcium Pyrophosphate Dihydrate Deposition Disease (CPPD), Gout, Low Back Pain, Osteoarthritis, Osteoarthritis of Hand or Wrist, Osteoarthritis of Hip, Osteoarthritis of Knee, Osteopenia, Osteoporosis, Polymyalgia Rheumatica (PMR), Raynaud's Disease, Rheumatoid Arthritis, Systemic Sclerosis

Certifications:

Internal Medicine, 1976, Rheumatology, 1980

Awards:

Healthgrades Honor Roll

Languages:

English

Education:

Medical School
Yale University School Of Medicine
Graduated: 1971
Yale New Haven Hospital
Graduated: 1972
Graduated: 1973
University Tex Health Science Center
Graduated: 1977

Fred Douglas Finkelman, Cincinnati OH

Specialties:

Rheumatologist

Address:

234 Goodman St, Cincinnati, OH 45219
222 Piedmont Ave, Cincinnati, OH 45219
Limited To Official Government Duties On, Cincinnati, OH 45267

Education:

Yale University, School of Medicine - Doctor of Medicine
Parkland Memorial Hospital - Fellowship - Rheumatology (Internal Medicine)
Yale New Haven Psychiatric Hospital - Residency - Internal Medicine

Board certifications:

American Board of Internal Medicine Certification in Internal Medicine, American Board of Internal Medicine Sub-certificate in Rheumatology (Internal Medicine)

Fred Finkelman, Cincinnati OH

Specialties:

Internal Medicine, Rheumatology, Pediatrics, Allergy

Work:

Cincinnati Va Medical Center
3200 Vine St, Cincinnati, OH 45220 University of Cincinnati
222 Piedmont Ave, Cincinnati, OH 45219 University Internal Med Assoc
234 Goodman St, Cincinnati, OH 45219

Education:

Yale University (1971)

Methods For Measuring In Vivo Cytokine Production

US Patent:

6824986, Nov 30, 2004

Filed:

Oct 6, 1998

Appl. No.:

09/167088

Inventors:

Fred D. Finkelman - Cincinnati OH
Suzanne C. Morris - Mason OH

Assignee:

University of Cincinnati - Cincinnati OH

International Classification:

G01N 3353

US Classification:

435 71, 435 75, 435 723, 435 724, 435 792, 435375, 4352872, 436506, 436507, 436512, 436513, 436548, 436177

Abstract:

The present invention involves techniques for evaluating in vivo cytokine production through the in vivo capture of secreting cytokines by labeled cytokine-binding reagents, followed by in vitro measurement of serum levels of captured cytokine. The methods of the present invention make use of the ability of a neutralizing antibody to a cytokine, when injected into a person or expierimental animal, to bind that cytokine and prevent its catabolism, excretion, or binding to a cytokine receptor. This causes the cytokine, which may normally have a very short in vivo half life, to accumulate in vivo as a cytokine/anti-cytokine antibody complex. If the anti-cytokine antibody is either labeled with a molecule that can be bound by another molecule (e. g. ; biotin, which is bound by avidin or streptavidin), or is itself capable of being bound by another molecule (e. g. ; a rat anti-cytokine antibody could be bound by an anti-rat immunoglobulin antibody), and the cytokine can also be bound by an antibody that recognizes a site distinct on the cytokine molecule from the site bound by the injected, neutralizing antibody, than the concentration of the cytokine/anti-cytokine complex in serum or other biological fluid can easily be assayed by a modified ELISA.