Inventors:
Frederick VanGoor - San Diego CA, US
Sara Ruah - La Jolla CA, US
Ashvani Singh - San Diego CA, US
Eric Olson - Belmont MA, US
Lewis Makings - Encinitas CA, US
Jesus Gonzalez - San Diego CA, US
James Rader - La Jolla CA, US
Fred Chambers - San Diego CA, US
Mark Miller - San Diego CA, US
Peter Grootenhuis - San Diego CA, US
Yahua Liu - San Diego CA, US
International Classification:
A61K031/4162, A61K031/4439, A61K031/415
Abstract:
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.