FRANK RICHARD TOPPO, MD
Osteopathic Medicine at Calvada Blvd, Pahrump, NV

5985860, Nov 16, 1999

Jun 7, 1994

8/255100

Frank Toppo - Las Vegas NV

A61K 3160

514159

Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other medicaments largely soluble in oil, alcohol, and/or water, are produced for transdermal delivery. The composition is manufactured by admixing an appropriate amount of oil surfactant with an appropriate amount of pharmaceutically approved co-solubilizer alcohol to establish a non aqueous phase. The oil surfactant may be a polyethoxylated oil such as castor oil. The co-solubilizer solubilizer may be isopropyl alcohol or virtually any other alcohols except for methanol. Thereafter, an appropriate amount of distilled water is slowly added to the homogeneous or non-aqueous phase to further reduce viscosity. The final admixture is a clear, oil-continuous solution having a viscosity no greater than 850 centistokes as measured by the VST Hoppler method at 25 degrees Celsius. The composition produced has the capacity to affect the individual surface skin cells (corneocytes) and allow the passage of medicaments to sub-dermal afflicted areas deep within the skin.

6048903, Apr 11, 2000

May 3, 1994

8/238214

Frank Toppo - Las Vegas NV

A61K 3105

514733

The level of heavy density lipoproteins (HDL) in the blood of a human subject can be in eased by administering dosages of between 50 and 1,000 milligrams of trans-resveratrol to the subject daily. This same dosage reduces the level of light density lipoproteins (LDL) in the blood of the subject. By increasing the blood level of HDL and decreasing the blood level of LDL in the subject, the risk of hypercholesterolemia in the subject is reduced.

2012001, Jan 19, 2012

Jul 24, 2006

11/491718

Frank Toppo - Pahrump NV, US

A61K 31/05, A61P 25/28

514733

Elderly individuals are administered dosages of Trans-resveratrol totaling between about 250 mg and 1 gram per day. Typically about 500 mg of Trans-resveratrol are orally administered to such individuals on a daily basis. As a result of the chemical action of Trans-resveratrol in the bodies of the subjects, Alzheimer's disease is prevented, or if already present, advancement is retarded and the existing mentally debilitating conditions of Alzheimer's disease are treated. A subject receiving the Trans-resveratrol experiences a reduction or illumination of the effects of Alzheimer's disease.

2004006, Apr 8, 2004

Oct 7, 2002

10/265372

Frank Toppo - Las Vegas NV, US

A61K035/78

424/730000, 424/747000, 424/765000, 424/777000

The delivery of St. John's Wort coupled separately with Natural Peppermint, Banana and Green Apple flavors via the nasal and or buccal mucosa in a ph appropriate solution, in homeopathic doses, is effective as an anorexant.