Inventors:
Robert D. Gray - Louisville KY
Arno F. Spatola - Louisville KY
Robert B. Miller - Vernon Hills IL
Frank R. Burns - Louisville KY
Christopher Paterson - Louisville KY
Assignee:
Research Corporation Technologies, Inc. - Tucson AZ
International Classification:
A61K 3700
Abstract:
The present invention relates to compounds of the formula:
R. sub. 1 SCH(R. sub. 2)CH(R. sub. 3)CO-AA. sub. 1 �AA. sub. 2 !. sub. m �AA. sub. 3 !. sub. n --X or
HSCH. sub. 2 �CH. sub. 2 CH(CH. sub. 3). sub. 2 !CO--Nal--NH. sub. 2
wherein Nal is L-3-(2-naphthyl)alanine;
m is the integer 0 or 1; n is an integer from 0-2;
AA. sub. 1 is a non-polar hydrophobic aromatic amino acid;
AA. sub. 2 is alanine, glycine, leucine, isoleucine or phenylalanine;
AA. sub. 3 is one of the twenty naturally occurring amino acids, preferably glutamine or arginine;
R. sub. 1 is hydrogen, alkyl having from 1-10 carbon atoms, alkanoyl having from 2-10 carbon atoms, or aroyl having from 7-10 carbon atoms;
R. sub. 2 is hydrogen or alkyl having from 1-6 carbon atoms;
R. sub. 3 is hydrogen, alkyl having from 2-10 carbon atoms, cycloalkyl having from 3-6 carbon atoms, aryl or arylalkyl, wherein aryl moieties have from 6-10 carbon atoms;
X is NH. sub.