FRANK I MARCUS, MD
Osteopathic Medicine at Campbell Ave, Tucson, AZ

5295484, Mar 22, 1994

May 19, 1992

7/885190

Frank I. Marcus - Tuscon AZ
Kullervo H. Hynynen - Tuscon AZ

Arizona Board of Regents for and on Behalf of the University of Arizona - Tucson AZ

A61B 800

12866003

The present invention employs ultrasonic energy delivered to myocardial tissue at frequencies sufficient to destroy the myocardial tissue implicated in the arrhythmic. More specifically, the present invention comprises an ultrasonic transducer mounted on a distal end of a catheter and at least one electrode associated with the distal end region of the catheter. The ultrasonic transducer may be a single crystal transducer or a phased array crystal transducer.

6423057, Jul 23, 2002

Jan 21, 2000

09/488878

Ding Sheng He - Tucson AZ
Michael Bosnos - Tucson AZ
Frank Marcus - Tucson AZ

The Arizona Board of Regents on behalf of The University of Arizona - Tucson AZ

A61B 1804

606 34, 606 45, 606 49

Impedance and capacitance-related parameters are monitored in the electrical circuit of a tissue-ablation apparatus wherein RF electrical power is administered at predetermined frequencies. Tissue temperature has been found to correlate well with low-frequency impedance, or with the resistive component of impedance at any frequency. Therefore, one or both of these parameters are calculated and tracked during the ablation procedure to estimate tissue temperature. Similarly, tissue lesion formation has been found to correlate well with changes in the capacitive component of tissue impedance. Thus, this parameter can be used to track tissue lesion formation during the ablation procedure. The ratio of tissue-to-blood interface with the ablation electrode is estimated by measuring impedance at a very low frequency and a very high frequency. The difference between these two values divided by the high-frequency value is taken to be a measure of such ratio. Alternatively, other electrical parameters indicative of changes in the capacitive component of the system may be measured and the ratio is calculated as a function of these changes with respect to a baseline value.

2006019, Aug 24, 2006

Jul 28, 2004

10/566152

Frank Marcus - Tucson AZ, US
Ding Sheng He - Tyngaboro MA, US

A61N 1/368

607017000

The patterns of contraction and relaxation of the heart before and during left ventricular or biventricular pacing are analyzed and displayed in real time mode to assist physicians to screen patients for cardiac resynchronization therapy, to set the optimal AN or right ventricle to left ventricle interval delay, and to select the site(s) of pacing that result in optimal cardiac performance. The system includes an accelerometer sensor (); a programmable pace maker (), a computer data analysis module (), and may also include a 2D and 3D visual graphic display of analytic results (), i.e. a Ventricular Contraction Map. A feedback network () provides direction for optimal pacing leads placement. The method includes selecting a location to place the leads of a cardiac pacing device, collecting seismocardiographic (SCG) data corresponding to heart motion during paced beats of a patient's heart, determining hemodynamic and electrophysiological parameters based on the SCG data, repeating the preceding steps for another lead placement location, and selecting a lead placement location that provides the best cardiac performance by comparing the calculated hemodynamic and electrophysiological parameters for each different lead placement location.

6978184, Dec 20, 2005

Jul 29, 2003

10/629881

Frank I. Marcus - Tucson AZ, US
Ding Sheng He - Tyngsboro MA, US

A61N001/05

607120

The patterns of contraction and relaxation of the heart before and during left ventricular or biventricular pacing are analyzed and displayed in real time mode to assist physicians to screen patients for cardiac resynchronization therapy, to set the optimal A-V or right ventricle to left ventricle interval delay, and to select the site(s) of pacing that result in optimal cardiac performance. The system includes an accelerometer sensor; a programmable pace maker, a computer data analysis module, and may also include a 2D and 3D visual graphic display of analytic results, i. e. a Ventricular Contraction Map. A feedback network provides direction for optimal pacing leads placement. The method includes selecting a location to place the leads of a cardiac pacing device, collecting seismocardiographic (SCG) data corresponding to heart motion during paced beats of a patient's heart, determining hemodynamic and electrophysiological parameters based on the SCG data, repeating the preceding steps for another lead placement location, and selecting a lead placement location that provides the best cardiac performance by comparing the calculated hemodynamic and electrophysiological parameters for each different lead placement location.

2006009, May 4, 2006

Dec 19, 2005

11/311039

Frank Marcus - Tucson AZ, US
Ding He - Tyngsboro MA, US

A61N 1/368

607017000, 600508000

A method for determining a change in function of a patient's heart that includes the steps of collecting seismocardiographic (SCG) data corresponding to a heart motion of the patient's heart; determining a hemodynamic parameter based on the SCG data; and comparing the parameter with a predetermined measure of cardiac performance. The system used with the method includes one or more accelerometer sensors, a computer data analysis module, and may also include a 2D and 3D visual graphic display of analytic results, i.e. a Ventricular Contraction Map.

2011006, Mar 17, 2011

Sep 15, 2010

12/882780

Ding Sheng He - Tyngsboro MA, US
Michael Bosnos - Tucson AZ, US
Frank I. Marcus - Tucson AZ, US

C.R. Bard - Murray Hill NJ

A61B 18/18, G06N 7/02

606 33, 706 52

Lesion size or volume prediction shortly after the onset of an ablation procedure can inform or control the ablation procedure. The prediction and/or control is made without regard to an actual detected temperature in the vicinity of the ablation electrodes. As a consequence, the system has utility with irrigated catheter constructions and other situations in which local irrigation in the vicinity of an ablation site would otherwise interfere with a prediction or control scheme that solely relies upon temperature measurements.