Inventors:
Frank Piraino - Waunakee WI
Curtis R. Brandt - Oregon WI
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
C07K 702
Abstract:
A substantially pure compound extracted from the mushroom Rozites caperata is disclosed. The compound disclosed is SEQ ID NO:1, a twelve amino acid peptide, covalently linked by the epsilon amino group of a carboxy terminal lysine to the carboxyl terminus of SEQ ID NO:2, or a pharmaceutically acceptable nontoxic salt of the compound. The disclosed compound inhibits replication of viruses having lipid bilayer envelopes. Also disclosed is a method for inhibiting replication of viruses having lipid bilayer envelopes. According to the method, such viruses can be inhibited by administering an effective amount of a substantially pure compound, which is SEQ ID NO:1 covalently to SEQ ID NO:2, or a pharmaceutically acceptable nontoxic salt of the compound.