DR. FRANK EDWARD CARROLL, M.D.
Radiology in Nashville, TN

6687333, Feb 3, 2004

Sep 28, 2001

09/964872

Frank E. Carroll - Nashville TN
Robert H. Traeger - Nashville TN
Marcus H. Mendenhall - Nashville TN
James W. Waters - Nashville TN
Glenn Edwards - Chapel Hill NC
Charles A. Brau - Nashville TN

Vanderbilt University - Nashville TN

G21G 400

378119, 378138

A system for generating tunable pulsed monochromatic X-rays includes a tabletop laser emitting a light beam that is counter-propagated against an electron beam produced by a linear accelerator. X-ray photon pulses are generated by inverse Compton scattering that occurs as a consequence of the “collision” that occurs between the electron beam and IR photons generated by the laser. The system uses a novel pulse structure comprising, for example, a single micropulse. In this way, pulses of very short X-rays are generated that are controllable on an individual basis with respect to their frequency, energy level, “direction,” and duration.

6332017, Dec 18, 2001

Jan 21, 2000

9/488898

Frank E. Carroll - Nashville TN
Robert H. Traeger - Nashville TN
Marcus H. Mendenhall - Nashville TN
James W. Waters - Nashville TN
Glenn Edwards - Nashville TN
Charles A. Brau - Nashville TN

Vanderbilt University - Nashville TN

H01J 3514

378119

A system for generating tunable pulsed monochromatic X-rays comprises a tabletop terawatt laser delivering 10 Joules of energy in 10 ps at a wavelength of 1. 1 microns. The light beam from the laser is counter-propagated against an electron beam produced by a linear accelerator. X-ray photons are generated by inverse Compton scattering that occurs as a consequence of the "collision" that occurs between the electron beam and IR photons generated by the laser. The system uses a novel pulse structure comprising, in a preferred embodiment, a single micropulse. The LINAC is configured to generate an electron beam having 1 nanocoulomb of charge in a microbunch having a pulse length of about 5 picoseconds or less (or an electron beam brightness of 10. sup. 12 A/m. sup. 2 -radian. sup. 2 @ 500 A). A beam alignment sub-system is used at the laser beam--electron beam interaction zone and directs the X-ray beam, in a preferred embodiment, through a beryllium window and onto mosaic crystals which divert the beam into a beam transport system toward the imaging target.

6327335, Dec 4, 2001

Apr 13, 1999

9/290436

Frank Carroll - Nashville TN

Vanderbilt University - Nashville TN

G01N 2320, G21K 100

378 85

A three-dimensional imaging device comprising a stationary monochromatic beam source projecting a beam onto a plurality of reflective mosaic crystals, wherein the plurality of mosaic crystals reflect the beam through a stationary object onto a stationary detector. A way for scanning the object includes moving the entire set of the mosaic crystals linearly along a line in the plane of the crystals, and rotating the entire plurality of crystals about an axis through the stationary beam source while maintaining the plurality of crystals in a fixed relative orientation. A potential application of the invention is to improve the accuracy of mammography in the diagnosis of breast cancer.

7486984, Feb 3, 2009

May 19, 2004

10/848151

Frank E. Carroll - Nashville TN, US

MXISystems, Inc. - Fairview TN

A61B 6/00, H01J 35/14

600436, 378138, 378119, 378 65, 600407, 600427

In embodiments of the invention, a radiosensitizer or other agent is relatively uniformly accumulated in the cells of a tumor. An external monochromatic x-ray beam, which is tuned to a predetermined energy level associated with k-edge effects in the agent, is then directed to the tumor. The monochromatic x-ray beam activates the release of additional localized radiation from the agent. The additional radiation destroys the DNA of at least some tumor cells, making those tumor cells incapable of reproduction and repair. In embodiments of the invention, a single monochromatic x-ray beam source is used for both imaging and radiotherapy.