Inventors:
Francis J. McMahon - Bethesda MD, US
Gonzalo E. Laje - Potomac MD, US
Silvia Paddock - Solna, SE
Husseini K. Manji - Cabin John MD, US
Alexander F. Wilson - Phoenix MD, US
Assignee:
Gov. of the United States of America, represented by the Secretary, Dept. of Health and - Rockville MD
Board fo Regents, The University of Texas System - Austin TX
International Classification:
G01N 33/50
Abstract:
The invention provides a method for determining the outcome of treatment with an antidepressant medication in a patient. In particular, the invention provides a method of screening patients to identify those patients with a decreased risk of non-response to treatment with antidepressant medication comprising: (a) obtaining a sample of genetic material from the patients, and (b) assaying the sample for the presence of a genotype in the patients which is associated with a decreased risk of non-response to treatment with antidepressant medication, wherein the genotype is characterized by a polymorphism in a HTR2A, GRIK4, BCL2, or a combination thereof.