Inventors:
Robert Baiocchi - Dublin OH, US
Chenglong Li - Dublin OH, US
Pui Kai Li - Galloway OH, US
Fengting Yan - Columbus OH, US
Assignee:
The Ohio State University Research Foundation - Columbus
International Classification:
A61K 31/4439, C07D 401/14, A61P 35/00, C07D 401/12
Abstract:
Disclosed herein are compositions and methods for cancer detection and treatment. Compounds that inhibit PRMT5 are contemplated, as are pharmaceutical compositions comprising a therapeutically effective amount of at least one PRMT5 inhibitor. In some embodiments pharmaceutical compositions further comprising at least one HDAC inhibitor are contemplated. Methods of treating disorders in a mammal by inhibiting PRMT5 by administering to a mammal, a therapeutically effective amount of a PRMT5 inhibitor are also disclosed.