Inventors:
Brian A. Donahue - Menlo Park CA
Jeffrey H. Toney - Westfield NJ
John M. Essigmann - Brookline MA
Stephen J. Lippard - Cambridge MA
Pieter M. Pil - Cambridge MA
Suzanne L. Bruhn - Cambridge MA
Steven J. Brown - Cambridge MA
Patti J. Kellett - Cincinnati OH
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
C17N 512
Abstract:
DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.