F. David Rollo
Medical Practice at Peach Hl Rd, Saratoga, CA
License number
Kentucky 21248
Issued Date
Apr 8, 1981
Expiration Date
Feb 28, 2009
Category
Nuclear Medicine
Type
Administration
Address
Address
15735 Peach Hill Rd, Saratoga, CA 95070
Education
State University of New York at Syracuse (Upstate), 1972
Phone
(408) 354-5371 (Work)
Professional information
Chelator-Targeting Ligand Conjugates For Cardiovascular Imaging
US Patent:
2011008, Apr 14, 2011
Filed:
Oct 7, 2010
Appl. No.:
12/900200
Inventors:
F. David Rollo - Saratoga CA, US
Jerry L. Bryant - Houston TX, US
Jerry L. Bryant - Houston TX, US
International Classification:
A61K 51/04, A61K 51/08, A61P 43/00
US Classification:
424 141, 424 173, 424 169
Abstract:
Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are methods of imaging a peripheral blood vessel in a subject by using a detectable amount of a radionuclide-labeled chelator-glucose analog conjugate. Also disclosed are methods of distinguishing a false positive nuclear cardiology scan from a true positive nuclear cardiology scan, methods of diagnosing congestive heart failure or cardiac ischemia that involve imaging a subject that has been administered a radionuclide-labeled chelator-glucose analog conjugate, and methods to distinguish viable from nonviable myocardium.
Efficient Synthesis Of Chelators For Nuclear Imaging And Radiotherapy: Compositions And Applications
US Patent:
2013003, Feb 14, 2013
Filed:
Jul 31, 2012
Appl. No.:
13/562879
Inventors:
David J. Yang - Sugar Land TX, US
Dongfang Yu - Pearland TX, US
Andrew S. Thompson - Mountainside NJ, US
F. David Rollo - Saratoga CA, US
Dongfang Yu - Pearland TX, US
Andrew S. Thompson - Mountainside NJ, US
F. David Rollo - Saratoga CA, US
International Classification:
A61K 51/08, A61K 38/05, A61P 35/00, A61P 35/02, A61K 49/22, A61K 49/04, A61P 9/00, A61P 9/10, A61K 49/00, A61K 49/14
US Classification:
424 169, 424 91, 514 11, 514 193, 424 93, 424 95, 424 94, 514 164, 514 194, 514 196, 514 195
Abstract:
Novel methods of synthesis of chelator-targeting ligand conjugates, compositions comprising such conjugates, and therapeutic and diagnostic applications of such conjugates are disclosed. The compositions include chelator-targeting ligand conjugates optionally chelated to one or more metal ions. Methods of synthesizing these compositions in high purity are also presented. Also disclosed are methods of imaging, treating and diagnosing disease in a subject using these novel compositions, such as methods of imaging a tumor within a subject and methods of diagnosing myocardial ischemia.