DR. EUGENE DE JUAN, MD
Medical Practice at Parnassus Ave, San Francisco, CA

2007026, Nov 22, 2007

Apr 2, 2007

11/695537

Eugene de Juan - San Francisco CA, US
Cary Reich - Los Gatos CA, US
Stephen Boyd - Murrieta CA, US
Hanson Gifford - Woodside CA, US
Mark Deem - Mountain View CA, US

FORSIGHT LABS, LLC - Menlo Park CA

A61F 2/02, A61K 31/215, A61K 38/13, A61P 27/02, A61P 27/06

424427000, 424484000, 424486000, 514011000, 514362000, 514530000, 514622000

An implant for insertion into a punctum of a patient comprises a body. The body has a distal end, a proximal end, and an axis therebetween. The distal end of the body is insertable distally through the punctum into the canalicular lumen. The body comprises a therapeutic agent included within an agent matrix drug core. Exposure of the agent matrix to the tear fluid effects an effective therapeutic agent release into the tear fluid over a sustained period. The body has a sheath disposed over the agent matrix to inhibit release of the agent away from the proximal end. The body also has an outer surface configured to engage luminal wall tissues so as to inhibit expulsion when disposed therein. In specific embodiments, the agent matrix comprises a non-bioabsorbable polymer, for example silicone in a non-homogenous mixture with the agent.

2008028, Nov 20, 2008

Feb 15, 2008

12/032627

Robert J. Greenberg - Los Angeles CA, US
Eugene de Juan - San Francisco CA, US
Mark S. Humayun - Glendale CA, US
Kelly H. McClure - Simi Valley CA, US
Neil Hamilton Talbot - La Crescenta CA, US
Jordan Matthew Neysmith - Pasadena CA, US
Brian V. Mech - Stevenson Ranch CA, US
James Singleton Little - Saugus CA, US
Mohamed Khaldi - Los Angeles CA, US

A61N 1/04

607115

The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.

2012018, Jul 26, 2012

Feb 7, 2012

13/367823

Deepank Utkhede - Surrey, CA
Robert W. Shimizu - Laguna Niguel CA, US
Rachna Jain - Milpitas CA, US
Stephen Boyd - Murrieta CA, US
Hanson S. Gifford - Woodside CA, US
Eugene de Juan - San Francisco CA, US
Cary J. Reich - Los Gatos CA, US

QLT INC. - Vancouver

B28B 11/12

264157

A solid drug core insert can be manufactured by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into a sheath body. The injection can be conducted at subambient temperatures. The mixture is cured to form a solid drug-matrix core. The therapeutic agent can be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. A surface of the solid drug core is exposed, for example by cutting the tube, and the exposed surface of the solid drug core releases therapeutic quantities of the therapeutic agent when implanted into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, for example with a material substantially impermeable to the therapeutic agent, such that the therapeutic quantities are released through the exposed surface, thereby avoiding release of the therapeutic agent to non-target tissues.

2009010, Apr 23, 2009

Sep 5, 2008

12/231984

Eugene de Juan - San Francisco CA, US
Cary J. Reich - Los Gatos CA, US
Stephen Boyd - Murrieta CA, US
Alan R. Rapacki - Redwood City CA, US
Robert W. Shimizu - Laguna Niguel CA, US
Valery Rubinchik - Richmond, CA
Charles Richard Kjellbotn - Qualicum Beach, CA

QLT Plug Delivery, Inc. - QPDI - Menlo Park CA

A61F 9/007, A61B 17/28

606206, 604 59, 606205, 604500

Insertion and extraction tool, systems, and methods for use with lacrimal implants. An insertion tool is disclosed that includes a proximal end, a distal end, and a tool body therebetween. The distal end includes a mechanical coupling to receive a cartridge preloaded with a lacrimal implant, and a plunger configured to dispense the lacrimal implant from a preloaded cartridge.

2014002, Jan 30, 2014

Oct 25, 2011

13/885135

Eugene De Juan ,Jr. - San Francisco CA, US
Yair Alster - Palo Alto CA, US
Cary J. Reich - Los Gatos CA, US
Ashley Tuan - Menlo Park CA, US
Angela K. MacFarlane - Menlo Park CA, US
Matt Clarke - Menlo Park CA, US
Brian Levy - New York NY, US

Nexis Vision ,Inc. - Menlo Park CA

G02C 7/04, G02C 7/02

351247, 35115974

Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering. The covering can be identified based on an inner corneal curvature and an outer corneal curvature and one or more of a limbus sag height or a conjunctival sag height. The covering may form a chamber when placed on the eye to pump tear liquid under at least a portion of the covering. The covering may comprise an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The covering may comprise a material having high oxygen permeability, for example silicone, with a wettable coating disposed on at least an upper surface of the coating.

2007019, Aug 16, 2007

Dec 22, 2006

11/615810

Eugene De Juan - San Francisco CA, US
Stephen Boyd - Murrieta CA, US
Mark Deem - Mountain View CA, US
Hanson Gifford - Woodside CA, US
Dan Rosenman - San Francisco CA, US

A61F 11/00

606108000

Methods and devices are adapted for implanting into the eye. An incision is formed in the cornea of the eye and a shunt is inserted through the incision into the anterior chamber of the eye. The shunt includes a fluid passageway. The shunt is passed along a pathway from the anterior chamber through the scleral spur of the eye into the suprachoroidal space and positioned in a first position such that a first portion of the fluid passageway communicates with the anterior chamber and a second portion of the fluid passageway communicates with the suprachoroidal space to provide a fluid passageway between the suprachoroidal space and the anterior chamber.