ETHAN SOUDRY, M.D.
Medical Practice at Forest Green Ct, Baltimore, MD
License number
Maryland 127459
Category
Medical Practice
Type
Otolaryngology
Address
Address
2416 Forest Green Ct, Baltimore, MD 21209
Phone
(443) 352-8992
Professional information
Hypermethylation Biomarkers For Detection Of Head And Neck Squamous Cell Cancer
US Patent:
2013007, Mar 21, 2013
Filed:
Mar 11, 2011
Appl. No.:
13/634321
Inventors:
David Sidransky - Baltimore MD, US
Ethan Soudry - Baltimore MD, US
Ethan Soudry - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C12Q 1/68
US Classification:
435 611
Abstract:
Differentially methylated oral squamous cell carcinoma (OSCC) biomarkers, identified in-vitro and validated in well-characterized surgical specimens, have shown poor clinical correlation in cohorts with different risk profiles. To overcome this lack of relevance we used the HumanMethylation27 BeadChip, publicly available methylation and expression array data, and Quantitative Methylation Specific PCR to uncover differential methylation in OSCC clinical samples with heterogeneous risk profiles. A two stage-design consisting of Discovery and Prevalence screens was used to identify differential promoter methylation and deregulated pathways in patients diagnosed with OSCC and head and neck squamous cell carcinoma. This Phase I Biomarker Development Trial identified a panel of differentially methylated genes in normal and OSCC clinical samples from patients with heterogeneous risk profiles. This panel may be useful for early detection and cancer prevention studies.