Inventors:
Ethan Lerner - Chestnut Hill MA, US
Vemuri B. Reddy - Ashland MA, US
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
A61K 31/438, A61P 17/04
Abstract:
Embodiments of the invention relates to methods of preventing itch in a subject using a therapeutically effective amount of a cysteine protease inhibitor. The itch is not associated with psoriasis and atopic dermatitis. The itch is also a non-histamine mediated itch. The inhibitor are directed to the cathepsin selected from the group consisting of cathepsin B, C, F, J, K, H, L, P, Q, S, W, X, V, and Z.