ERNEST JOSEPH PRISBE
Pilots at Eastbrook Ave, Los Altos, CA
License number
California A2761268
Issued Date
Feb 2017
Expiration Date
Feb 2019
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
11333 Eastbrook Ave, Los Altos, CA 94024
Professional information
Prodrugs Of Phosphonate Nucleotide Analogues And Methods For Selecting And Making Same
US Patent:
2002011, Aug 29, 2002
Filed:
Jul 20, 2001
Appl. No.:
09/909560
Inventors:
Mark Becker - Belmont CA, US
Harlan Chapman - La Honda CA, US
Tomas Cihlar - Foster City CA, US
Eugene Eisenberg - San Carlos CA, US
Gong-Xin He - Fremont CA, US
Michael Kernan - Pacifica CA, US
William Lee - Los Altos CA, US
Ernest Prisbe - Los Altos CA, US
John Rohloff - Mountain View CA, US
Mark Sparacino - Morgan Hill CA, US
Harlan Chapman - La Honda CA, US
Tomas Cihlar - Foster City CA, US
Eugene Eisenberg - San Carlos CA, US
Gong-Xin He - Fremont CA, US
Michael Kernan - Pacifica CA, US
William Lee - Los Altos CA, US
Ernest Prisbe - Los Altos CA, US
John Rohloff - Mountain View CA, US
Mark Sparacino - Morgan Hill CA, US
Assignee:
GILEAD SCIENCES, INC.
International Classification:
C12Q001/70
US Classification:
435/005000
Abstract:
A novel method is provided for screening prodrugs of methoxyphosphonate nucleotide analogues to identify prodrugs selectively targeting desired tissues with antiviral or antitumor activity. This method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5)
having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided. Also provided is an improved method for the use of magnesium alkoxide for the preparation of starting materials and compounds for use herein.
Preparation Of Carbocyclic Compounds
US Patent:
5859284, Jan 12, 1999
Filed:
Aug 23, 1996
Appl. No.:
8/701942
Inventors:
Kenneth M. Kent - Sunnyvale CA
Choung U. Kim - San Carlos CA
Lawrence R. McGee - Pacifica CA
John D. Munger - Alviso CA
Ernest J. Prisbe - Los Altos CA
Michael J. Postich - San Mateo CA
John C. Rohloff - Mountain View CA
Daphne E. St. John - San Francisco CA
Matthew A. Williams - Foster City CA
Lijun Zhang - Foster City CA
Choung U. Kim - San Carlos CA
Lawrence R. McGee - Pacifica CA
John D. Munger - Alviso CA
Ernest J. Prisbe - Los Altos CA
Michael J. Postich - San Mateo CA
John C. Rohloff - Mountain View CA
Daphne E. St. John - San Francisco CA
Matthew A. Williams - Foster City CA
Lijun Zhang - Foster City CA
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
C07C 69757, C07D20326, C07D31746, C07D30700
US Classification:
560125
Abstract:
The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
Preparation Of Cyclohexene Carboxylate Derivatives
US Patent:
2002005, May 16, 2002
Filed:
Dec 19, 2000
Appl. No.:
09/740504
Inventors:
Kenneth Kent - Sunnyvale CA, US
Choung Kim - San Carlos CA, US
Lawrence McGee - Pacifica CA, US
John Munger - Alviso CA, US
Ernest Prisbe - Los Altos CA, US
Michael Postich - Walnut Creek CA, US
John Rohloff - Mountain View CA, US
Daphne Kelly - San Francisco CA, US
Matthew Williams - Foster City CA, US
Lijun Zhang - Foster City CA, US
Choung Kim - San Carlos CA, US
Lawrence McGee - Pacifica CA, US
John Munger - Alviso CA, US
Ernest Prisbe - Los Altos CA, US
Michael Postich - Walnut Creek CA, US
John Rohloff - Mountain View CA, US
Daphne Kelly - San Francisco CA, US
Matthew Williams - Foster City CA, US
Lijun Zhang - Foster City CA, US
Assignee:
GILEAD SCIENCES, INC.
International Classification:
C07D317/44, C 07D 3 3/00, C 07D 2 3/26, C 07C 3 3/00
US Classification:
549/436000, 549/546000, 548/961000, 558/052000
Abstract:
The present invention provides new synthetic methods and compositions. In particular, new methods of preparing intermediates useful in the synthesis of neuraminidase inhibitors and compositions useful as intermediates that are themselves useful in the synthesis of neuraminidase inhibitors are provided.
Compounds And Methods For Making And Using Same
US Patent:
5750729, May 12, 1998
Filed:
Feb 25, 1997
Appl. No.:
8/806575
Inventors:
Petr Alexander - San Mateo CA
Ernest J. Prisbe - Los Altos CA
Ernest J. Prisbe - Los Altos CA
Assignee:
Gilead Sciences,Inc. - Foster City CA
International Classification:
C07F 928, C07F32700, C07F33332, C07G 300
US Classification:
549216
Abstract:
In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame retardants, diagnostic oligonucleotides and immunogens.
Compounds And Methods For Making And Using Same
US Patent:
5767100, Jun 16, 1998
Filed:
Mar 13, 1996
Appl. No.:
8/615670
Inventors:
Petr Alexander - San Mateo CA
Ernest J. Prisbe - Los Altos CA
Ernest J. Prisbe - Los Altos CA
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
A61K 4800
US Classification:
514 44
Abstract:
In accordance with this invention novel compounds are provided that are selected from saturated and unsaturated pyrans and furans substituted with at least a phosphonate group and a heterocyclic base. These compounds are useful as antiinfectives, flame retardants, diagnostic oligonucleotides and immunogens.
Prodrugs Of Phosphonate Nucleotide Analogues And Methods For Selecting And Making Same
US Patent:
2006002, Feb 2, 2006
Filed:
Feb 24, 2004
Appl. No.:
10/785497
Inventors:
Mark Becker - Belmont CA, US
Harlan Chapman - La Honda CA, US
Tomas Cihlar - Foster City CA, US
Eugene Eisenberg - San Carlos CA, US
Gong-Xin He - Fremont CA, US
Michael Kernan - Pacifica CA, US
William Lee - Los Altos CA, US
Ernest Prisbe - Los Altos CA, US
John Rohloff - Mountain View CA, US
Mark Sparacino - Morgan Hill CA, US
Harlan Chapman - La Honda CA, US
Tomas Cihlar - Foster City CA, US
Eugene Eisenberg - San Carlos CA, US
Gong-Xin He - Fremont CA, US
Michael Kernan - Pacifica CA, US
William Lee - Los Altos CA, US
Ernest Prisbe - Los Altos CA, US
John Rohloff - Mountain View CA, US
Mark Sparacino - Morgan Hill CA, US
International Classification:
C12Q 1/00, C12Q 1/70
US Classification:
435004000, 435005000
Abstract:
A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a)
having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
Nucleotide Analogs
US Patent:
6225460, May 1, 2001
Filed:
Feb 10, 1999
Appl. No.:
9/247497
Inventors:
Norbert W. Bischofberger - San Carlos CA
Robert J. Jones - Millbrae CA
Murty N. Arimilli - Fremont CA
Kuei-Ying Lin - Fremont CA
Michael S. Louie - San Mateo CA
Lawrence R. McGee - Pacifica CA
Ernest J. Prisbe - Los Altos CA
William A. Lee - Los Altos CA
Kenneth C. Cundy - Belmont CA
Robert J. Jones - Millbrae CA
Murty N. Arimilli - Fremont CA
Kuei-Ying Lin - Fremont CA
Michael S. Louie - San Mateo CA
Lawrence R. McGee - Pacifica CA
Ernest J. Prisbe - Los Altos CA
William A. Lee - Los Altos CA
Kenneth C. Cundy - Belmont CA
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
C07H 1904
US Classification:
536 261
Abstract:
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
Nucleotide Analogs
US Patent:
2009014, Jun 11, 2009
Filed:
Sep 16, 2008
Appl. No.:
12/211745
Inventors:
Norbert W. Bischofberger - Hillsborough CA, US
Robert J. Jones - Millbrae CA, US
Murty N. Armilli - Oak Ridge NC, US
Kuei-Ying Lin - Sunnyvale CA, US
Michael S. Louie - San Mateo CA, US
Lawrence R. McGee - Pacificia CA, US
Ernest J. Prisbe - Los Altos CA, US
William A. Lee - Los Altos CA, US
Kenneth C. Cundy - Belmont CA, US
Robert J. Jones - Millbrae CA, US
Murty N. Armilli - Oak Ridge NC, US
Kuei-Ying Lin - Sunnyvale CA, US
Michael S. Louie - San Mateo CA, US
Lawrence R. McGee - Pacificia CA, US
Ernest J. Prisbe - Los Altos CA, US
William A. Lee - Los Altos CA, US
Kenneth C. Cundy - Belmont CA, US
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
C07F 9/02
US Classification:
544244
Abstract:
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
Nucleotide Analogs
US Patent:
2001004, Nov 15, 2001
Filed:
Mar 7, 2001
Appl. No.:
09/801164
Inventors:
Norbert Bischofberger - San Carlos CA, US
Robert Jones - Millbrae CA, US
Murty Arimilli - Fremont CA, US
Kuei-Ying Lin - Fremont CA, US
Michael Louie - San Mateo CA, US
Lawrence McGee - Pacifica CA, US
Ernest Prisbe - Los Altos CA, US
William Lee - Los Altos CA, US
Kenneth Cundy - Belmont CA, US
Robert Jones - Millbrae CA, US
Murty Arimilli - Fremont CA, US
Kuei-Ying Lin - Fremont CA, US
Michael Louie - San Mateo CA, US
Lawrence McGee - Pacifica CA, US
Ernest Prisbe - Los Altos CA, US
William Lee - Los Altos CA, US
Kenneth Cundy - Belmont CA, US
Assignee:
GILEAD SCIENCES, INC.
International Classification:
C07H021/04, C07K009/00, C07H021/02
US Classification:
536/023100, 530/322000
Abstract:
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.
Nucleotide Analogs
US Patent:
5886179, Mar 23, 1999
Filed:
Dec 29, 1995
Appl. No.:
8/581147
Inventors:
Murty N. Arimilli - Fremont CA
Norbert W. Bischofberger - San Carlos CA
Robert J. Jones - Millbrae CA
William A. Lee - Los Altos CA
Ernest J. Prisbe - Los Altos CA
Norbert W. Bischofberger - San Carlos CA
Robert J. Jones - Millbrae CA
William A. Lee - Los Altos CA
Ernest J. Prisbe - Los Altos CA
Assignee:
Gilead Sciences, Inc. - Foster City CA
International Classification:
C07D23922, C07F 902, A61K 31675
US Classification:
544243
Abstract:
Nucleotide phosphonate esters characterized by the presence of an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise an ester bond that is hydrolyzed in vivo to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for their synthesis and use are described.