Eric William Bernhard Larsen
Engineers at American St, Philadelphia, PA
License number
Colorado 41423
Issued Date
Aug 24, 2007
Renew Date
Nov 1, 2015
Expiration Date
Oct 31, 2017
Type
Professional Engineer
Address
Address
1400 N American St SUITE 205, Philadelphia, PA 19122
Professional information
Modulation Of Cellular Apoptosis And Methods For Treating Cancer
US Patent:
2002004, Apr 25, 2002
Filed:
Sep 13, 2001
Appl. No.:
09/950836
Inventors:
Wafik El-Deiry - Bryn Mawr PA, US
Eric Bernhard - Philadelphia PA, US
Timothy Burns - Philadelphia PA, US
E. McDonald - Philadelphia PA, US
Eric Bernhard - Philadelphia PA, US
Timothy Burns - Philadelphia PA, US
E. McDonald - Philadelphia PA, US
International Classification:
A61K048/00, A61K038/17, C12N015/86
US Classification:
424/093210, 435/320100, 514/012000
Abstract:
This invention relates to modulating cellular apoptosis in an animal by regulating the quantity of functional KILLER/DR5 receptor protein molecules in the target cell(s) of said animal, increasing the effectiveness of certain therapies such as chemotherapy and radiotherapy. Such modulation increases the difference in toxicity response between target cell(s) and non-target cell(s) in response to a therapy or treatment and comprises upregulation of wild-type proteins in cells targeted for increased apoptosis or upregulation of loss-of-function proteins in cells targeted for decreased apoptosis. The methods of this invention comprise administering a nucleic acid sequence encoding a wild-type KILLER/DR5 receptor protein or a nucleic acid sequence encoding a loss-of-function mutant KILLER/DR5 receptor protein to said animal. The pharmaceutical compositions of this invention comprise a loss-of-function KILLER/DR5 receptor protein. The isolated nucleic acid sequences of this invention comprise wild-type KILLER/DR5 receptor nucleic acid sequence(s) bearing one or more point mutations at selected amino acid(s). A target of this invention is spleen and gastrointestinal cancer cells.
Sensitization Of Cells To Radiation And And Chemotherapy
US Patent:
2002003, Mar 21, 2002
Filed:
Apr 15, 1997
Appl. No.:
08/839248
Inventors:
W. GILLIES MCKENNA - PHILADELPHIA PA, US
RUTH J. MUSCHEL - PHILADELPHIA PA, US
ERIC J. BERNHARD - PHILADELPHIA PA, US
SAID M. SEBTI - TAMPA FL, US
ANDREW D. HAMILTON - PITTSBURGH PA, US
RUTH J. MUSCHEL - PHILADELPHIA PA, US
ERIC J. BERNHARD - PHILADELPHIA PA, US
SAID M. SEBTI - TAMPA FL, US
ANDREW D. HAMILTON - PITTSBURGH PA, US
International Classification:
A61M036/14, A61K051/00, A01N037/18, A61K038/00, C12Q001/00, C12Q001/68, G01N033/53, A61K038/16, A61K031/70, A01N043/04, A61K039/395, A61K031/545, G01N033/52
US Classification:
435/004000, 514/002000, 514/044000, 435/006000, 435/007100, 424/130100, 424/001110
Abstract:
The invention relates to a method of conferring radiation sensitivity on a tumor cell comprising administering to the cell an inhibitor of a protein product which participates in the ras signalling pathway, whereby inhibition of the protein product confers radiation sensitivity on the cell.