ERIC P SANDGREN
Veterinary in Philadelphia, PA
License number
Pennsylvania BV006045L
Category
Veterinary Medicine
Type
Veterinarian
Address
Address
Philadelphia, PA 19107
Professional information
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Method Of Preparing Recombinant Proteins In Transgenic Animals Containing Metallothionein Gene Elements That Bestow Tissue-Independent Copy Number-Dependent, Position-Indepedent Gene Expression
Method Of Preparing Recombinant Proteins In Transgenic Animals Containing Metallothionein Gene Elements That Bestow Tissue-Independent Copy Number-Dependent, Position-Indepedent Gene Expression
US Patent:
5583009, Dec 10, 1996
Filed:
Dec 8, 1992
Appl. No.:
7/986963
Inventors:
Richard Palmiter - Seattle WA
Eric P. Sandgren - Philadelphia PA
Ralph L. Brinster - Gladwyne PA
Eric P. Sandgren - Philadelphia PA
Ralph L. Brinster - Gladwyne PA
Assignee:
University of Washington - Seattle WA
The Trustees of the University of Pennsylvania - Philadelphia PA
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
C12P 2102, C12P 2100, C12N 1509, C07H 2104
US Classification:
435691
Abstract:
Vertebrate gene locus control regions linked to a structural gene of interest and inserted into a transgenic animal are capable of bestowing tissue-independent, copy number-dependent, position-independent gene expression. Recombinant proteins of interest encoded by structural genes linked to the metallothionein locus control regions may be prepared following expression in transgenic animal hosts.