Inventors:
Steven F Dowdy - La Jolla CA, US
Eric L. Snyder - Brookline MA, US
Assignee:
The Regents of the University of California - San Diego CA
International Classification:
A61K 49/00, C07K 7/00, C12N 9/72, C12N 9/70, C12N 15/00, C12N 15/11, C12N 5/06, A61K 38/02
US Classification:
424 91, 530330, 530329, 530328, 530327, 435215, 435216, 435375, 514 2, 536 234, 4353201
Abstract:
The disclosure provides fusion polypeptides and constructs useful in targeting molecules including diagnostics and therapeutics to a cell type of interest. The fusion constructs include a protein transduction domain, a ligand domain and a cargo domain. Also provided are methods of treating disease and disorders such as cell proliferative disorders.