DR. ERIC L ZIRBES, RPH, PHD
Pharmacy at Hawkins Dr, Iowa City, IA
License number
Iowa 16952
Category
Pharmacy
Type
Pharmacist
Address
Address
200 Hawkins Dr, Iowa City, IA 52242
Phone
(319) 384-9603
Professional information
Process For The Production Of Piperidine Derivatives With Microorganisms
US Patent:
7232908, Jun 19, 2007
Filed:
Aug 11, 2003
Appl. No.:
10/638841
Inventors:
Peter C. Michels - Des Moines IA, US
Eric L. Zirbes - Coralville IA, US
Eric L. Zirbes - Coralville IA, US
Assignee:
AMR Technology, Inc. - Manchester Center VT
International Classification:
C07D 211/22, C12P 17/12
US Classification:
546239, 546240, 546241, 435122, 435135, 435136, 514317
Abstract:
The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products. Suitable microorganisms can be from any one of the genus of , and. In another aspect of the invention, starting compounds are incubated in the presence of under conditions effective to produce piperidine derivative products.
Process For The Production Of Piperidine Derivatives With Microorganisms
US Patent:
2002008, Jul 4, 2002
Filed:
Jan 4, 2001
Appl. No.:
09/754786
Inventors:
Peter Michels - Des Moines IA, US
Eric Zirbes - Coralville IA, US
Eric Zirbes - Coralville IA, US
International Classification:
C07D211/22, C07D211/18
US Classification:
546/216000, 546/236000, 546/237000
Abstract:
The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB:
wherein n is 0 or 1; Ris hydrogen or hydroxy; Ris hydrogen; or, when n is 0, Rand Rtaken together form a second bond between the carbon atoms bearing Rand R, provided that when n is 1, Rand Rare each hydrogen; Ris —COOH or —COOR; Ris an alkyl or aryl moiety; A, B, and D are the substituents of their rings, each of which may be different or the same, and are selected from the group consisting of hydrogen, halogens, alkyl, hydroxy, and alkoxy. This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB:
wherein Ris —CHand R, R, A, B, and D are defined above. in the presence of a microorganism under conditions effective to produce the product compound. The microorganism can be from the genus Streptomyces, Stemphylium, Gliocladium, Bacillus, Botrytis, Cyathus, Rhizopus, Pycniodosphora, Psuedomonas, Helicostylum, Aspergillus, Mucor, Gelasinospora, Rhodotorula, Candida, Mycobacterium, or Pennicillium. Alternatively, the microorganism can be
Process For The Production Of Piperidine Derivatives With Microorganisms
US Patent:
7691615, Apr 6, 2010
Filed:
Jan 17, 2007
Appl. No.:
11/624096
Inventors:
Peter C. Michels - Des Moines IA, US
Eric L. Zirbes - Coralville IA, US
Eric L. Zirbes - Coralville IA, US
Assignee:
Albany Molecular Research, Inc. - Albany NY
International Classification:
C12P 17/21
US Classification:
435122, 514317, 546239, 546240, 546241
Abstract:
The present invention relates to the production of a product compound having a structure according to Formulae IA and/or IB:This process involves incubating a starting compound having a structure according to Formulae IIA and/or IIB:.