DR. ERIC DAVID JACOBSEN, MD
Osteopathic Medicine in Boston, MA
License number
Massachusetts 219248
Category
Osteopathic Medicine
Type
Hematology & Oncology
Address
Address
2
44 Binney St Dana 1B30, Boston, MA 02115
51 Medway St, Norfolk, MA 02056
51 Medway St, Norfolk, MA 02056
Phone
(617) 632-6633
(617) 632-5168 (Fax)
(508) 528-7563
(617) 632-5168 (Fax)
(508) 528-7563
Personal information
See more information about ERIC DAVID JACOBSEN at radaris.comName
Address
Phone
51 Medway St, Norfolk, MA 02056
40 Greenmeadow Ln, Granby, MA 01033
122 Leary Dr, Holyoke, MA 01040
83 Leary Dr, Holyoke, MA 01040
40 Greenmeadow Ln, Granby, MA 01033
Professional information
See more information about ERIC DAVID JACOBSEN at trustoria.com
Dr. Eric D Jacobsen, Framingham MA - MD (Doctor of Medicine)
Dr. Eric D Jacobsen, Framingham MA - MD (Doctor of Medicine)
Specialties:
Hematology, Medical Oncology, Oncology
Age:
50
Address:
761 Worcester Rd, Framingham 01701
(508) 788-1700 (Phone)
(508) 788-1700 (Phone)
Certifications:
Hematology, 2010, Internal Medicine, 2002, Medical Oncology, 2005
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
761 Worcester Rd, Framingham 01701
Brigham and Women's Hospital
75 Francis St, Boston 02115
Massachusetts General Hospital
55 Fruit St, Boston 02114
North Shore Medical Center - Salem Hospital
81 Highland Ave, Salem 01970
Brigham and Women's Hospital
75 Francis St, Boston 02115
Massachusetts General Hospital
55 Fruit St, Boston 02114
North Shore Medical Center - Salem Hospital
81 Highland Ave, Salem 01970
Education:
Medical School
University Of Connecticut School Of Medicine
Graduated: 1999
Johns Hopkins Hospital
Graduated: 2000
Graduated: 2002
Harvard Cancer Center/Dana Farber Cancer Institute
Graduated: 2005
University Of Connecticut School Of Medicine
Graduated: 1999
Johns Hopkins Hospital
Graduated: 2000
Graduated: 2002
Harvard Cancer Center/Dana Farber Cancer Institute
Graduated: 2005
Process For Synthesizing 7-Alkynyl-4- Aminoquinazolines And A Related Intermediate
Process For Synthesizing 7-Alkynyl-4- Aminoquinazolines And A Related Intermediate
US Patent:
2010004, Feb 25, 2010
Filed:
Mar 2, 2007
Appl. No.:
12/224412
Inventors:
Eric N. Jacobsen - Boston MA, US
International Classification:
C07D 239/72
US Classification:
544287
Abstract:
A process for synthesizing 7-alkynyl-4-aminoquinazolines from 7-haloquinazolines is disclosed. In one specific synthesis, 4-[N-3-chloro-4-fluorophenyl)]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butynyl]-6-[N-methyl acrylamide]quinazoline is prepared from 7-chloro-6-nitro-3H-quinazolin-4-one. Also disclosed is an intermediate useful in the syntheses of 7-alkynyl-4-ammoquinaozolines and a process for making the intermediate. The 7-alkynyl-4-aminoquinaozolines prepared by processes of the invention are useful as pharmaceutically active compounds.
Main-Group Metal Based Asymmetric Catalysts And Applications Thereof
Main-Group Metal Based Asymmetric Catalysts And Applications Thereof
US Patent:
6521561, Feb 18, 2003
Filed:
May 1, 1998
Appl. No.:
09/071842
Inventors:
Eric N. Jacobsen - Boston MA
Matthew S. Sigman - Somerville MA
Matthew S. Sigman - Somerville MA
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
B01J 3100
US Classification:
502162, 502163, 502167, 502168, 502171
Abstract:
The present invention relates to a method and catalysts for the stereoselective addition of a nucleophile to a reactive -bond of a substrate. The chiral, non-racemic catalysts of the present invention constitute the first examples of catalysts for nucleophilic additions that comprise a main-group metal and a tri- or tetra-dentate ligand.
Parallel Combinatorial Approach To The Discovery And Optimization Of Catalysts And Uses Thereof
Parallel Combinatorial Approach To The Discovery And Optimization Of Catalysts And Uses Thereof
US Patent:
6709824, Mar 23, 2004
Filed:
Sep 24, 2001
Appl. No.:
09/962012
Inventors:
Eric N. Jacobsen - Boston MA
Matthew S. Sigman - Somerville MA
Matthew S. Sigman - Somerville MA
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C12Q 168
US Classification:
435 6, 540484, 502172, 502200, 5483361, 548537, 548557, 560103, 560138
Abstract:
The present invention provides methods and compositions, i. e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.
Hydrolytic Kinetic Resolution Of Epoxides
Hydrolytic Kinetic Resolution Of Epoxides
US Patent:
6693206, Feb 17, 2004
Filed:
Aug 22, 2002
Appl. No.:
10/225869
Inventors:
Yi Liu - Weymouth MA
Marcello DiMare - Belmont MA
Salvatore Anthony Marchese - Malden MA
Eric N. Jacobsen - Boston MA
Serge Jasmin - Watertown MA
Marcello DiMare - Belmont MA
Salvatore Anthony Marchese - Malden MA
Eric N. Jacobsen - Boston MA
Serge Jasmin - Watertown MA
Assignee:
Rhodia Chirex, Inc. - MA
International Classification:
C07D30132
US Classification:
549541, 549513, 549540
Abstract:
The present invention provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. The process includes the step of contacting oxygen and mixture including a racemic chiral epoxy compound, a non-racemic Co(II) complex catalyst, an aromatic carboxylic acid and water, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound. The present invention also provides a process for the preparation of an enantiomerically enriched non-racemic chiral diol and an enantiomerically enriched non-racemic chiral epoxy compound by a hydrolytic kinetic resolution reaction. This process includes the step of: contacting a racemic chiral epoxy compound and water in the presence of a non-racemic complex of Co(III) having an aryl carboxylate counter-anion, at a temperature and length of time sufficient to produce a mixture of said non-racemic chiral diol and said non-racemic chiral epoxy compound.
Hydrolytic Kinetic Resolution Of Cyclic Substrates
Hydrolytic Kinetic Resolution Of Cyclic Substrates
US Patent:
6448414, Sep 10, 2002
Filed:
Jul 5, 2001
Appl. No.:
09/899516
Inventors:
Eric N. Jacobsen - Boston MA
Makoto Tokunaga - Wako, JP
Jay F. Larrow - Irvine CA
Makoto Tokunaga - Wako, JP
Jay F. Larrow - Irvine CA
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C07D31736
US Classification:
549230, 502158, 540604, 544264, 548965, 548969, 549513, 549518, 562 64
Abstract:
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.
Hydrolytic Kinetic Resolution Of Cyclic Substrates
Hydrolytic Kinetic Resolution Of Cyclic Substrates
US Patent:
6800766, Oct 5, 2004
Filed:
Jul 26, 2002
Appl. No.:
10/206143
Inventors:
Eric N. Jacobsen - Boston MA
Makoto Tokunaga - Saitama, JP
Jay F. Larrow - Irvine CA
Makoto Tokunaga - Saitama, JP
Jay F. Larrow - Irvine CA
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
C08D30100
US Classification:
549230, 502158, 540604, 544264, 548965, 548969, 549296, 549513, 549518, 562 64, 568866
Abstract:
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.
Asymmetric Cycloaddition Reactions
Asymmetric Cycloaddition Reactions
US Patent:
6211370, Apr 3, 2001
Filed:
Feb 23, 1999
Appl. No.:
9/255480
Inventors:
Eric N. Jacobsen - Boston MA
Scott E. Schaus - Cambridge MA
Alexander G. Dossetter - Somerville MA
Timothy F. Jamison - Cambridge MA
Scott E. Schaus - Cambridge MA
Alexander G. Dossetter - Somerville MA
Timothy F. Jamison - Cambridge MA
Assignee:
Harvard University - Cambridge MA
International Classification:
C07D30918, C07D32706, C07D33502
US Classification:
546 25
Abstract:
The present invention relates to a process for stereoselective cycloaddition reactions which generally comprises a cycloaddition reaction between a pair of substrates, each either chiral or prochiral, that contain reactive. pi. -systems, in the presence of a non-racemic chiral catalyst, to produce a stereoisomerically enriched product. The present invention also relates to novel asymmetric catalyst complexes comprising a metal and an asymmetric tridentate ligand.
Parallel Combinatorial Approach To The Discovery And Optimization Of Catalysts And Uses Thereof
Parallel Combinatorial Approach To The Discovery And Optimization Of Catalysts And Uses Thereof
US Patent:
2004023, Nov 25, 2004
Filed:
Mar 17, 2004
Appl. No.:
10/802670
Inventors:
Eric Jacobsen - Boston MA, US
Matthew Sigman - Somerville MA, US
Matthew Sigman - Somerville MA, US
International Classification:
C12Q001/68, C12P021/04
US Classification:
435/006000
Abstract:
The present invention provides methods and compositions, i.e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.
Parallel Combinatorial Approach To The Discovery And Optimization Of Catalysts And Uses Thereof
Parallel Combinatorial Approach To The Discovery And Optimization Of Catalysts And Uses Thereof
US Patent:
6316616, Nov 13, 2001
Filed:
Apr 22, 1998
Appl. No.:
9/064462
Inventors:
Eric N. Jacobsen - Boston MA
Matthew S. Sigman - Somerville MA
Matthew S. Sigman - Somerville MA
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
B01J 3102, C07C 69017, C07C27518, C07D22312
US Classification:
540484
Abstract:
The present invention provides methods and compositions, i. e. synthetic libraries of candidate compounds, useful in the discovery and optimization of compounds which catalyze at least one chemical transformation. In certain instances, the subject compounds catalyze a chemoselective, regioselective, stereoselective or enantioselective transformation.