ERIC ALAN KLEIN
Medical Practice in Cleveland, OH

2010018, Jul 22, 2010

Dec 22, 2009

12/645181

Robert H. Silverman - Beachwood OH, US
Eric A. Klein - Shaker Heights OH, US
Christopher J. Weight - Shaker Heights OH, US
Carvell T. Nguyen - University Heights OH, US
Jaydip Das Gupta - Mayfield Heights OH, US

C12Q 1/70

435 5

The present invention relates to the identification of Xenotropic murine leukemia virus (XMRV) nucleic acid by polymerase chain reaction (PCR) analysis (e.g., real time PCR (RT/PCR); nested RT/PCR using Tth DNA polymerase and Hot start polymerase) and the uses thereof. In particular, the invention provides methods for the detection, and in particular early detection, of XMRV in RNA isolated from samples (e.g., urine samples; expressed prostate secretion (EPS)) of prostate cancer patients and normal individuals.

8263085, Sep 11, 2012

Sep 24, 2007

11/903756

Robert H. Silverman - Beachwood OH, US
Eric A. Klein - Shaker Heights OH, US
Graham Casey - Pasadena CA, US
Joseph DeRisi - San Francisco CA, US
Don Ganem - San Francisco CA, US

The Cleveland Clinic Foundation - Cleveland OH
The Regents of the University of California - Oakland CA

A61K 39/21, C12N 5/071, C12N 7/00

4242071, 536 2372

The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e. g. , in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e. g. , cancer such as prostate cancer); methods of detecting asymptomatic cancer (e. g. , prostate cancer); methods of identifying an individual at risk for developing cancer (e. g. , prostate cancer); and kits for detecting the virus.

2013004, Feb 14, 2013

Jul 17, 2012

13/551286

Robert H. Silverman - Beachwood OH, US
Eric A. Klein - Shaker Heights OH, US
Graham Casey - Pasadena CA, US
Joseph DeRisi - San Francisco CA, US
Don Ganem - San Francisco CA, US

The Regents of the University of California - Oakland CA
The Cleveland Clinic Foundation - Cleveland OH

C12N 7/00, C07K 14/15

4352351, 530350

The present invention provides for isolated nucleic acid sequences encoding viruses; isolated polypeptides comprising amino acid sequences of the virus; vectors comprising the viral nucleic acid sequences; cells comprising the vectors; antibodies and antigen binding fragments thereof which have binding specificity for the virus; methods of detecting or screening for the virus (e.g., in an individual); methods of identifying agents that inhibit the virus; methods of inducing an immune response to the virus; methods of treating disease associated with the presence of XMRV in an individual (e.g., cancer such as prostate cancer); methods of detecting asymptomatic cancer (e.g., prostate cancer); methods of identifying an individual at risk for developing cancer (e.g., prostate cancer); and kits for detecting the virus.