Inventors:
Andrew F. Russo - Iowa City IA, US
Eric A. Kaiser - Iowa City IA, US
Ana Recober - Iowa City IA, US
Adisa Kuburas - North Liberty IA, US
Ann C. Raddant - Iowa City IA, US
Brian Robert Kovacevich - Snohomish WA, US
John A. Latham - Seattle WA, US
Jeffrey T.L. Smith - Bellevue WA, US
Leon F. Garcia-Martinez - Woodinville WA, US
International Classification:
A61K 39/395, A61K 51/10, A61P 25/06, A61P 25/00, A61P 27/02, A61P 27/12, A61P 13/00, A61P 35/00, A61P 31/16, A61P 31/04, A61P 3/00, A61P 31/12, A61P 25/24, A61P 25/04, A61P 29/00, A61P 37/08, A61P 15/00, A61P 19/10, A61K 49/00
US Classification:
424 169, 4241581, 424 92, 4241331, 4241351, 4241781
Abstract:
The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.