Inventors:
Daniel A. Lawrence - Ann Arbor MI, US
Cory Emal - Ann Arbor MI, US
Jacqueline Cale - Minneapolis MN, US
Enming J. Su - Ann Arbor MI, US
Mark Warnock - Brighton MI, US
Jeanne A. Cupp - Fenton MI, US
Assignee:
EASTERN MICHIGAN UNIVERSITY - Ypsilamti MI
International Classification:
A61K 38/16, C07C 69/76, A61K 31/235, C07C 233/64, A61K 31/166, C07D 401/12, A61K 31/444, C07D 241/04, A61K 31/4965, C07D 237/04, A61K 31/50, C07D 265/30, A61K 31/5375, C07D 311/00, A61K 31/351, C07H 15/203, A61K 31/7028, A61P 3/10, A61P 3/04, A61P 25/28, A61P 9/04, A61P 19/02
US Classification:
514 8, 560 76, 514533, 564158, 514616, 560 61, 546261, 514335, 544387, 51425501, 544224, 514247, 544158, 5142388, 549417, 514460, 536 182, 514 25
Abstract:
The invention relates to plasminogen activator-1 (PAI-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated PAI-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated PAI-1, cholesterol, or lipid levels.