Inventors:
Emmanuel AKALA - Mitchellville MD, US
Simeon ADESINA - Lanham MD, US
International Classification:
C08G 63/06, C08G 63/08, C08G 63/60, A61K 31/337, A61K 31/704, A61J 3/00, C08G 63/66, A61P 35/00, B82Y 5/00
US Classification:
514 34, 525450, 525437, 528354, 428402, 514449, 264 4, 977773
Abstract:
The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monmer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.