Inventors:
Philip Leder - Chestnut Hill MA
Brian Seed - Boston MA
Ben Z. Stanger - Brookline MA
Tae-Ho Lee - Daejeon, KR
Emily Kim - Chestnut Hill MA
Assignee:
President and Fellows of Harvard College - Cambridge MA
The General Hospital Corporation - Boston MA
International Classification:
C12N 120, C07H 2102, C07H 2104, C12P 2106
Abstract:
Disclosed is a protein, designated RIP, which contains a death domain at its carboxy terminus and a kinase domain at its amino terminus. RIP interacts with the Fas/APO-1 intracellular domain and the TNFR1 intracellular domain. When expressed in transformed host cells, recombinant RIP promotes apoptosis. Also disclosed are DNA molecules encoding RIP, anti-RIP antibodies, and screening methods for discovering inhibitors of RIP-dependent apoptosis.