Inventors:
Ian MacLachlan - Mission, CA
Vandana Sood - Vancouver, CA
Thomas W. Geisbert - Albany TX, US
Lisa E. Hensley - Frederick MD, US
Elliott Kagan - Potomac MD, US
Assignee:
Protiva Biotherapeutics, Inc. - Burnaby BC
International Classification:
A61K 31/713, C07H 21/02, A61K 9/00, A61P 31/14, B82Y 5/00
US Classification:
424400, 536 245, 514 44 A, 977773, 977915
Abstract:
The present invention provides siRNA molecules that target Filovirus gene expression and methods of using such siRNA molecules to silence Filovirus gene expression. The present invention also provides nucleic acid-lipid particles that target Filovirus gene expression comprising an siRNA that silences Filovirus gene expression, a cationic lipid, and a non-cationic lipid.