Inventors:
Zalman S. Agus - Cherry Hill NJ
Ellie Kelepouris - Merion PA
Martin Morad - Philadelphia PA
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 912, A61K 31435
Abstract:
Methods for the therapy of cystic fibrosis, Bartter's syndrome, and secretory diarrheas, and for diuretic treatment, by administering to a patient dodecahydro-7,14-methano-2H,6H-di-pyrido[1,2-a:1',2'-e][1,5]diazocine or a pharmaceutically acceptable derivative thereof are disclosed. The formulations include an aerosol formulation comprising the active ingredient in association with an aerosol propellant.