Inventors:
Elaine Tuomanen - Brownsville TN, US
Elizabeth R. Mann - Germantown TN, US
Assignee:
ST. JUDE CHILDREN'S RESEARCH HOSPITAL - Memphis TN
International Classification:
C07K 14/315
US Classification:
4241901, 530350, 536 234, 4353201
Abstract:
Compositions and methods are provided for the prevention and treatment of bacterial infections, including pneumococal infections. Compositions provided herein comprise a variety of immunogenic fusion proteins, wherein at least one polypeptide component of a given fusion protein comprises a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof. Methods are provided for the prevention and treatment of bacterial infections, including pneumococcal infections by employing the various immunogenic fusion proteins having at least one polypeptide component comprising a CbpA polypeptide and/or a cytolysoid polypeptide, or an active variant or fragment thereof.