Inventors:
Richard J. Roman - Brookfield WI
John R. Falck - Dallas TX
Magdalena Alonso-Galicia - New Berlin WI
Elizabeth R. Jacobs - Milwaukee WI
David R. Harder - Waukesha WI
Assignee:
MCW Research Foundation - Milwaukee WI
International Classification:
A61K 3120
US Classification:
514560, 514381, 514382, 514417, 514423, 514558, 514559, 514601, 514602, 514603, 514604, 514605, 514613, 514616, 514671, 514675, 514678, 514706, 514713, 514731, 514733, 514738, 514739, 514627, 514826, 514866
Abstract:
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid and 20-,21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z),8(Z),11(Z),14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z),15(Z)-dienoic acid.