DR. ELIZABETH J FRANZMANN, MD
Medical Practice at 10 Ave, Miami, FL

2005021, Sep 29, 2005

Mar 28, 2005

11/090705

Elizabeth Franzmann - Miami FL, US
Vinata Lokeshwar - Miami FL, US
Erika Reategui - Miami FL, US

University of Miami - Miami FL

C12Q001/68, G01N033/574

435007230, 435006000

A method of diagnosing head and neck squamous cell carcinoma (HNSCC) includes obtaining a sample form a subject and measuring soluble CD44 (solCD44). The sample may be a body fluid such as saliva. An elevated level of solCD44 in the sample relative to baseline from a normal population of subjects is indicative of the presence of HNSCC. The degree of elevation can be indicative of the severity of disease. The HNSCC can be detected in an early stage and also as a recurrence of the disease.

2013022, Aug 29, 2013

Feb 4, 2011

13/021442

Luis A.G. Da Cruz - Toronto, CA
Elizabeth Jane Franzmann - Miami FL, US

UNIVERSITY OF MIAMI - Miami FL
HOFFMANN-LA ROCHE INC. - Nutley NJ

C07K 16/28

424 149, 4241561, 4241331, 4241781, 424 854, 53038885

This invention relates to the staging, diagnosis, and treatment of cancerous diseases, particularly to the use of monoclonal antibodies, antigen binding fragments thereof, and/or cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB, chemotherapeutic agents, and conjugates thereof, as a means for initiating a cytotoxic response to human head and neck squamous cell carcinomas. The invention further relates to binding assays, which utilize the monoclonal antibodies, antigen binding fragments thereof, and/or CDMAB of the instant invention. The cancerous disease modifying antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells. In particular aspects, the CDMAB used in the methods of the invention is an anti-CD44 antibody, which may be the antibody produced by the hybridoma deposited with the ATCC having accession number PTA-4621 and/or a chimeric or humanized version thereof.

2009032, Dec 31, 2009

May 14, 2007

12/300523

Elizabeth J. Franzmann - Miami FL, US
Vinata B. Lokeshwar - Miami FL, US

University of Miami - Miami FL

G01N 33/574

435 723

Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.

2012011, May 10, 2012

Dec 13, 2011

13/324526

Elizabeth J. Franzmann - Miami FL, US
Vinata B. Lokeshwar - Miami FL, US

UNIVERSITY OF MIAMI - Miami FL

G01N 33/573, G01N 33/577, G01N 33/566

435 74, 435 75, 435 794

Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.