ELIZABETH ANN RUTLEDGE, RD
Dietitian and Nutritionist at Hoyt Ave, Everett, WA
License number
Washington DI60688683
Category
Dietitian and Nutritionist
Type
Dietitian, Registered
Address
Address
2
4220 Hoyt Ave, Everett, WA 98203
790 Remington Blvd, Lemont, IL 60440
790 Remington Blvd, Lemont, IL 60440
Phone
(425) 258-5330
(425) 258-6116 (Fax)
(630) 296-2223
(630) 759-9510 (Fax)
(425) 258-6116 (Fax)
(630) 296-2223
(630) 759-9510 (Fax)
Personal information
See more information about ELIZABETH ANN RUTLEDGE at radaris.comName
Address
Phone
409 119Th St S, Tacoma, WA 98444
3243 Spyglass Dr, Bellingham, WA 98226
9302 76Th St SW, Lakewood, WA 98498
7331 S Artesian Ave, Chicago, IL 60629
6906 W B St, Belleville, IL 62223
Professional information
See more information about ELIZABETH ANN RUTLEDGE at trustoria.com
Mutants Of Gad65 And Ian5 Relating To Diabetes
Mutants Of Gad65 And Ian5 Relating To Diabetes
US Patent:
2004014, Jul 22, 2004
Filed:
May 29, 2003
Appl. No.:
10/449741
Inventors:
Ake Lernmark - Seattle WA, US
Dong Luo - Kenmore WA, US
Armand MacMurray - Seattle WA, US
Ruth Ettinger - Seattle WA, US
Daniel Moralejo - Seattle WA, US
Elizabeth Rutledge - Lake Stevens WA, US
Dong Luo - Kenmore WA, US
Armand MacMurray - Seattle WA, US
Ruth Ettinger - Seattle WA, US
Daniel Moralejo - Seattle WA, US
Elizabeth Rutledge - Lake Stevens WA, US
Assignee:
University of Washington - Seattle WA
International Classification:
G01N033/53, G01N033/567, C07K014/47
US Classification:
435/007200, 530/350000
Abstract:
GAD65 mutants which lack a C-terminal conformational epitope are disclosed. The GAD65 mutants can be used in diagnostic methods for detecting the presence of or risk of developing type 1 diabetes. Also disclosed are compositions relating to the Ian5 gene, including Ian5 polynucleotides, Ian5 polypeptides and antibodies thereto, and expression vectors, recombinant cells comprising the Ian5 polynucleotides, and genetically modified animal models. In particular, the compositions include those relating to truncated mutant Ian5 polypeptides lacking a significant portion of the C-terminus. Mutations in the Ian5 gene locus that result in a truncated Ian5 protein are associated with lymphopenia and type 1 diabetes in mammals. The compositions are useful, for example, in methods of screening for agonists or antagonists of Ian5 pathways, such as to identify candidate agents for diabetes drug development, or for developing gene therapy for type 1 diabetes or a related disorder. Also disclosed are diagnostic methods relating to Ian5 gene mutations.