Inventors:
Elisabeth Adderson - Memphis TN, US
John Bohnsack - Salt Lake City UT, US
Assignee:
University of Utah Research Foundation - Salt Lake City UT
St. Jude Children's Research Hospital - Memphis TN
International Classification:
C07K 14/315, C07K 16/40, A61K 39/09, C07K 16/12, C12Q 1/68, G01N 33/68
US Classification:
4241391, 435 611, 435 734, 435188, 435325, 435331, 435348, 435362, 435365, 435366, 435419, 4352523, 43525231, 43525233, 43525234, 43525235, 4352542, 4353201, 536 237, 530350, 4241901, 5303879, 5303913
Abstract:
This invention provides an isolated nucleic acid encoding a polypeptide comprising amino acid sequences of a streptococcal matrix adhesion E (EmaE) polypeptide. Antibodies to the EmaE polypeptide and immunogenic fragments thereof are also provided. This invention provides pharmaceutical compositions, immunogenic compositions, vaccines, and diagnostic and therapeutic methods of use of the isolated polypeptide, antibodies thereto, and nucleic acids.