ELISABETH A MORRIS
Veterinary in Sherborn, MA
License number
Massachusetts 2798
Issued Date
Jun 14, 1984
Expiration Date
Feb 28, 2017
Type
Veterinarian
Address
Address
Sherborn, MA 01770
Professional information
Methods And Compositions For Healing And Repair Of Articular Cartilage
US Patent:
6727224, Apr 27, 2004
Filed:
Jan 28, 2000
Appl. No.:
09/493545
Inventors:
Renwen Zhang - Rutherford NJ
Diane Peluso - Marshfield MA
Elisabeth Morris - Sherborn MA
Diane Peluso - Marshfield MA
Elisabeth Morris - Sherborn MA
Assignee:
Genetics Institute, LLC. - Cambridge MA
International Classification:
A61K 3800
US Classification:
514 12, 514 2, 514 44, 128898, 424 9321, 424423, 424422, 424 937, 4353201, 435402, 606152, 623 11
Abstract:
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
Method For Treating Adamts-5-Associated Disease
US Patent:
7390833, Jun 24, 2008
Filed:
Nov 8, 2004
Appl. No.:
10/983981
Inventors:
Elisabeth A. Morris - Sherborn MA, US
Sonya Glasson - Belmont MA, US
Jason Shaoyun Xiang - Winchester MA, US
Sonya Glasson - Belmont MA, US
Jason Shaoyun Xiang - Winchester MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A01N 41/02, A01N 37/34, A01N 37/30, A01N 37/12, A01N 37/44, A61K 31/275, A61K 31/205, A61K 31/195, A61K 31/255
US Classification:
514518, 514520, 514555, 514562
Abstract:
The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulfonamide compound. The invention is based, in part, on the discovery that transgenic animals that do not express functional ADAMTS-5 show a reduction in the degree of osteoarthritis after the induction of osteoarthritis as compared to WT animals. Furthermore, the ADAMTS-5 transgenic animals have reduced aggrecanase activity in articular tissue as compared to WT animals. These animals are good models for ADAMTS-5-associated diseases, and for screening of drugs useful in the treatment and/or prevention of these diseases. There are no other animal models in which the deletion of the activity of a single gene is capable of abrogating the course of osteoarthritis. Accordingly, these animals also show that osteoarthritis can be prevented and/or treated by administering to a subject an ADAMTS-5 inhibitory agent and particularly an agent capable of inhibiting the aggrecanase activity of ADAMTS-5.
Methods And Compositions For Healing And Repair Of Articular Cartilage
US Patent:
2008016, Jul 10, 2008
Filed:
Oct 30, 2007
Appl. No.:
11/929031
Inventors:
Renwen Zhang - Rutherford NJ, US
Diane Peluso - Marshfield MA, US
Elisabeth Morris - Sherborn MA, US
Diane Peluso - Marshfield MA, US
Elisabeth Morris - Sherborn MA, US
International Classification:
A61K 38/18, A61P 19/00
US Classification:
514 12
Abstract:
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
Methods And Compositions For Healing And Repair Of Articular Cartilage
US Patent:
2008016, Jul 10, 2008
Filed:
Oct 30, 2007
Appl. No.:
11/928977
Inventors:
Renwen Zhang - Ruthrford NJ, US
Diane Peluso - Marshfield MA, US
Elisabeth Morris - Sherborn MA, US
Diane Peluso - Marshfield MA, US
Elisabeth Morris - Sherborn MA, US
International Classification:
A61K 38/17
US Classification:
514 12
Abstract:
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.
Methods And Compositions For Healing And Repair Of Articular Cartilage
US Patent:
7323445, Jan 29, 2008
Filed:
Feb 18, 2004
Appl. No.:
10/779638
Inventors:
Renwen Zhang - Rutherford NJ, US
Diane Peluso - Marshfield MA, US
Elisabeth Morris - Sherborn MA, US
Diane Peluso - Marshfield MA, US
Elisabeth Morris - Sherborn MA, US
Assignee:
Genetics Institute, LLC - Cambridge MA
International Classification:
A61K 38/00
US Classification:
514 12, 514 2, 424422, 424423, 424 9321, 424 937, 435 71, 4353201, 435402
Abstract:
Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration and/or functional repair of articular cartilage tissue.
Aggrecanase Molecules
US Patent:
2003010, Jun 5, 2003
Filed:
Jan 25, 2002
Appl. No.:
10/057487
Inventors:
Lisa Racie - Acton MA, US
Natalie Twine - Goffstown NH, US
Michael Agostino - Andover MA, US
Neil Wolfman - Dover MA, US
Elisabeth Morris - Sherborn MA, US
Natalie Twine - Goffstown NH, US
Michael Agostino - Andover MA, US
Neil Wolfman - Dover MA, US
Elisabeth Morris - Sherborn MA, US
Assignee:
American Home Products Corporation
International Classification:
C07H021/04, C12N009/64, C12P021/02, C12N005/06
US Classification:
536/023200, 435/069100, 435/320100, 435/325000, 435/226000
Abstract:
Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
Chondrogenic Potential Of Human Bone Marrow-Derived Cd105+ Cells By Bmp
US Patent:
2002016, Nov 14, 2002
Filed:
Feb 19, 2002
Appl. No.:
10/078808
Inventors:
Manas Majumdar - Burlington MA, US
Elisabeth Morris - Sherborn MA, US
Elisabeth Morris - Sherborn MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K038/18
US Classification:
514/012000
Abstract:
Compositions of BMPs useful for cartilage repair and methods employing these compositions are disclosed. Compositions comprising non-tissue culture expanded cells isolated from bone marrow and treated with BMPs useful for cartilage repair and methods employing these compositions are also disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
Biaryl Sulfonamides And Methods For Using Same
US Patent:
2005013, Jun 16, 2005
Filed:
Dec 1, 2004
Appl. No.:
11/000711
Inventors:
Jason Xiang - Winchester MA, US
Steve Tam - Wellesley MA, US
Yonghan Hu - Burlington MA, US
David How - Nyack NY, US
Darrin Hopper - New York NY, US
Matthew Vera - Royersford PA, US
Joshua Sabatini - White Plains NY, US
Thomas Rush - Lexington MA, US
Elisabeth Morris - Sherborn MA, US
Katy Georgiadis - Belmont MA, US
Steve Tam - Wellesley MA, US
Yonghan Hu - Burlington MA, US
David How - Nyack NY, US
Darrin Hopper - New York NY, US
Matthew Vera - Royersford PA, US
Joshua Sabatini - White Plains NY, US
Thomas Rush - Lexington MA, US
Elisabeth Morris - Sherborn MA, US
Katy Georgiadis - Belmont MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K031/50, A61K031/4965, A61K031/505, A61K031/47
US Classification:
514247000, 514275000, 514255060, 514310000, 514313000, 514352000, 514355000, 514367000, 514370000, 514374000, 514375000, 514406000, 514562000, 544239000, 544330000, 544406000, 546159000, 546146000, 544304000, 546304000, 546314000, 562430000
Abstract:
The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
Use Of Rxr Agonists For The Treatment Of Osteoarthritis
US Patent:
2009020, Aug 20, 2009
Filed:
Feb 11, 2009
Appl. No.:
12/369425
Inventors:
Sunil Nagpal - Collegeville PA, US
Zhiyong Yang - Newton MA, US
Elisabeth Morris - Sherborn MA, US
Edward R. Lavallie - Harvard MA, US
Zhiyong Yang - Newton MA, US
Elisabeth Morris - Sherborn MA, US
Edward R. Lavallie - Harvard MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 31/44, A61K 31/203, A61K 31/202, A61K 31/20, C12Q 1/68, A61P 19/02
US Classification:
514356, 514559, 514560, 514558, 435 6
Abstract:
Disclosed herein are methods of preventing and treating osteoarthritis through the use of RXR agonists.
Aggrecanase Molecules
US Patent:
2002015, Oct 17, 2002
Filed:
Oct 16, 2001
Appl. No.:
09/978979
Inventors:
Lisa Racie - Acton MA, US
Natalie Twine - Goffstown NH, US
Michael Agostino - Andover MA, US
Neil Wolfman - Dover MA, US
Elisabeth Morris - Sherborn MA, US
Natalie Twine - Goffstown NH, US
Michael Agostino - Andover MA, US
Neil Wolfman - Dover MA, US
Elisabeth Morris - Sherborn MA, US
Assignee:
Genetics Institute, Inc. - Cambridge MA
International Classification:
C07H021/04
US Classification:
536/023200
Abstract:
Novel aggrecanase proteins and the nucleotides sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.