Inventors:
Eliot H. Ohlstein - Glenmoore PA
Assignee:
Boehringer Mannheim Pharmaceutical Corporation - Rockville MD
SmithKline Beecham Corp. - Rockville MD
International Classification:
A61K 3140
Abstract:
A new use of, and method of treatment of atherosclerosis using, a compound selected from the group consisting essentially of compounds of Formula I: ##STR1## wherein: R. sub. 1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl;
R. sub. 2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylalkyl selected from benzyl, phenylethyl and phenylpropyl;
R. sub. 3 is hydrogen or lower alkyl of up to 6 carbon atoms;
R. sub. 4 is hydrogen or lower alkyl of up to 6 carbon atoms, or when X is oxygen, R. sub. 4 together with R. sub. 5 can represent --CH. sub. 2 --O--;
X is a valency bond, --CH. sub. 2, oxygen or sulfur;
Ar is selected from phenyl, naphthyl, indanyl and tetrahydronaphthyl;
R. sub. 5 and R. sub. 6 are individually selected from hydrogen, fluorine, chlorine, bromine, hydroxyl, lower alkyl of up to 6 carbon atoms, a --CONH. sub. 2 -- group, lower alkoxy of up to 6 carbon atoms, benzyloxy, lower alkylthio of up to 6 carbon atoms, lower alkysulphinyl of up to 6 carbon atoms and lower alkylsulphonyl of up to 6 carbon atoms; or
R. sub. 5 and R. sub.