PROF. ELAZER R. EDELMAN, M.D., PH.D.
Osteopathic Medicine at Francis St, Boston, MA
License number
Massachusetts 55990
Category
Osteopathic Medicine
Type
Cardiovascular Disease
Address
Address
2
75 Francis St, Boston, MA 02115
30 Warren St, Brookline, MA 02445
30 Warren St, Brookline, MA 02445
Phone
(617) 253-1569
(617) 253-2514 (Fax)
(617) 253-2514 (Fax)
Personal information
See more information about ELAZER R. EDELMAN at radaris.comName
Address
Phone
30 Warren St, Brookline, MA 02445
30 Warren St, Brookline, MA 02445
71 Baxter Rd, Brookline, MA 02445
91 Baxter Rd, Brookline, MA 02146
91 Baxter Rd, Brookline, MA 02146
Professional information
Expandable Medical Device For Delivery Of Beneficial Agent
US Patent:
8187321, May 29, 2012
Filed:
Sep 7, 2005
Appl. No.:
11/222202
Inventors:
John F. Shanley - Redwood City CA, US
Neal L. Eigler - Pacific Palisades CA, US
Kinam Park - West Lafayette IN, US
Elazer R. Edelman - Brookline MA, US
Neal L. Eigler - Pacific Palisades CA, US
Kinam Park - West Lafayette IN, US
Elazer R. Edelman - Brookline MA, US
Assignee:
Innovational Holdings, LLC - New Brunswick NJ
International Classification:
A61F 2/06
US Classification:
623 142, 623 144, 623 146, 427 224
Abstract:
An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
Elazer R Edelman, Boston MA
Specialties:
Cardiologist
Address:
75 Francis St, Boston, MA 02115
Education:
Harvard Medical School - Doctor of Medicine
Brigham & Women's Hospital - Fellowship - Cardiology
Brigham & Women's Hospital - Residency - Family Medicine
Brigham & Women's Hospital - Fellowship - Cardiology
Brigham & Women's Hospital - Residency - Family Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine
Elazer Reuven Edelman, Boston MA
Specialties:
Internal Medicine, Cardiovascular Disease, Cardiology, General Practice
Work:
Brigham & Women's Hospital
75 Francis St, Boston, MA 02115
75 Francis St, Boston, MA 02115
Education:
Harvard University(1983)
Tissue-Engineered Endothelial And Epithelial Implants Differentially And Synergistically Regulate Tissue Repair
US Patent:
2013006, Mar 14, 2013
Filed:
Aug 10, 2012
Appl. No.:
13/571494
Inventors:
Elazer R. Edelman - Brookline MA, US
Brett G. Zani - Arlington MA, US
Brett G. Zani - Arlington MA, US
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61K 35/12, A61P 17/02, A61P 1/00, A61P 15/00, A61P 11/00, A61P 9/00
US Classification:
424 937
Abstract:
Endothelial implants restore vascular homeostasis after injury without reconstituting vascular architecture. Endothelial cells line the vascular epithelium and underlying vasa vasorum precluding distinction between cellular controls. Unlike blood vessels, the airway epithelium is highly differentiated and distinct from endothelial cells that line the bronchial vasa allowing investigation of the differential control tissue engineered cells may provide in airways and blood vessels. Through airway injury and cell culture models, tissue engineered implants of the bronchial epithelium and endothelium were found to promote synergistic repair of the airway through biochemical regulation of the airway microenvironment. While epithelial cells modulate local tissue composition and reaction, endothelial cells preserve the epithelium; together their relative impact was enhanced suggesting both cell types act synergistically for airway repair.
Materials And Methods For Minimally-Invasive Administration Of A Cell-Containing Flowable Composition
US Patent:
2008011, May 22, 2008
Filed:
Dec 6, 2005
Appl. No.:
11/792284
Inventors:
Helen Marie Nugent - Needham MA, US
Elazer Edelman - Brookline MA, US
Steve Bollinger - Mansfield MA, US
Elazer Edelman - Brookline MA, US
Steve Bollinger - Mansfield MA, US
International Classification:
A61K 9/14, A61K 35/00, A61P 29/00
US Classification:
424484, 424 937
Abstract:
The disclosed invention is based on the discovery that a cell-based therapy can be used to treat, ameliorate, manage and/or reduce the progression of clinical sequelae associated with vascular interventions or cardiovascular diseases, particularly occlusive thrombosis, restenosis, intimal hyperplasia, inflammation and vasodilation. The invention further benefits from the additional discovery that a heretofore undescribed implantable flowable composition is capable of sustaining a confluent population of sufficiently viable cells which can be effectively administered via a minimally-invasive surgical procedure without diminishing the clinical effectiveness or the viability of the cells. The disclosed invention can be used to treat vasculature as well as non-vascular tubular structures such as a fallopian tube.
Systems And Methods For Treating Lumenal Valves
US Patent:
2011011, May 12, 2011
Filed:
Oct 6, 2010
Appl. No.:
12/899231
Inventors:
Adam Groothuis - Swampscott MA, US
Adrian Ebner - Asuncion, PY
Peter Markham - Kingston NH, US
Elazer R. Edelman - Brookline MA, US
Adrian Ebner - Asuncion, PY
Peter Markham - Kingston NH, US
Elazer R. Edelman - Brookline MA, US
International Classification:
A61F 2/24
US Classification:
623 21, 623 212
Abstract:
The present embodiments relate to systems and methods for treating lumenal valves. Particularly, and in accordance with one aspect, the present disclosure is directed to methods and systems for partial or complete replacement of lumenal valves. An exemplary catheter in accordance with the disclosure includes an elongate body having a proximal end and a distal end, and a retractable sheath mounted on the elongate body proximate the distal end. The sheath and elongate body cooperating to define a first annularly-shaped compartment between the body and sheath. The catheter further includes a valve prosthesis mounted in the compartment, the prosthesis having proximal and distal ends connected to a means for deploying the valve prosthesis from the catheter.
Controlled Release Systems Containing Heparin And Growth Factors
US Patent:
5100668, Mar 31, 1992
Filed:
Jun 14, 1988
Appl. No.:
7/206520
Inventors:
Elazer R. Edelman - Brookline MA
Robert S. Langer - Somerville MA
Michael Klagsburn - Newton MA
Edith Mathiowitz - Brookline MA
Robert S. Langer - Somerville MA
Michael Klagsburn - Newton MA
Edith Mathiowitz - Brookline MA
Assignee:
Massachusetts Institute of Technology - Cambridge MA
International Classification:
A61F 1300, A61F 200, A61K 914
US Classification:
424422
Abstract:
A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses growth factors bound to biocompatible substrates via heparin or heparin derived compounds to maintain the bioactivity of the growth factors. A growth factor bound to a heparin coated substrate can be used independently as a controlled release device, or can be incorporated into a reservoir or matrix type controlled release devices to further enhance the controlled release properties. The stabilized growth factors can be implanted into a patient, thereby providing a means for producing an in vivo controlled release of a growth factor to the patient.
Extraluminal Regulation Of The Growth And Repair Of Tubular Structures In Vivo
US Patent:
5540928, Jul 30, 1996
Filed:
Apr 28, 1994
Appl. No.:
8/234714
Inventors:
Elazer R. Edelman - Brookline MA
David H. Adams - Boston MA
Morris J. Karnovsky - Newton Centre MA
David H. Adams - Boston MA
Morris J. Karnovsky - Newton Centre MA
Assignee:
President and Fellows of Harvard College - Cambridge MA
International Classification:
A61F 200, A61K 922
US Classification:
424422
Abstract:
A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
Stent Concept For Minimization Of Deployment Related Wall Shear And Injury
US Patent:
2003009, May 15, 2003
Filed:
Oct 16, 2002
Appl. No.:
10/271843
Inventors:
Elazer Edelman - Brookline MA, US
Kumaran Kolandaivelu - Boston MA, US
Kumaran Kolandaivelu - Boston MA, US
International Classification:
A61F002/06
US Classification:
623/001150
Abstract:
A stent device for minimizing deployment related injuries. The stent device includes at least one structural block of a desired length and includes a plurality of projection struts. The projection struts each have a defined shape, and form a foldable pattern so that the stent device folds onto itself. An expansion mechanism is stored within the structural block. The expansion mechanism unfolds the foldable patterns of the projection struts using expansion so that minimal damage occurs to a vessel wall.
Methods And Compositions For Enhancing Vascular Access
US Patent:
2010020, Aug 12, 2010
Filed:
Nov 27, 2009
Appl. No.:
12/626823
Inventors:
HELEN MARIE NUGENT - Needham MA, US
Elazer Edelman - Brookline MA, US
Anupam Dalal - Walnut Creek CA, US
Stephen August Bollinger - Mansfield MA, US
Scott Epperly - East Bridgewater MA, US
Elazer Edelman - Brookline MA, US
Anupam Dalal - Walnut Creek CA, US
Stephen August Bollinger - Mansfield MA, US
Scott Epperly - East Bridgewater MA, US
International Classification:
A61F 2/06
US Classification:
623 141
Abstract:
Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality.