Inventors:
Patrick G. Johnston - Bethesda MD
Carmen J. Allegra - North Potomac MD
Edwin R. Fisher - Pittsburgh PA
Assignee:
The United States of America as represented by the Department of Health
and Human Services - Washington DC
International Classification:
G01N 3353, C07K 100, C07K 1600
Abstract:
Methods for determining whether a chemotherapeutic treatment is appropriate for patients afflicted with gastrointestinal cancers, comprising;
(a) obtaining a solid tumor tissue sample from the patient;
(b) measuring a thymidylate synthase expression level in the tissue sample; and
(c) comparing the thymidylate synthase expression level with a group of standard tumor tissue samples, the standards having known thymidylate synthase expression levels and known responses to the chemotherapeutic treatment, to determine if that chemotherapeutic treatment is appropriate for the patient.